Essentials of glycobiology / edited by Ajit Varki ... [et al.]. -- Fourth edition. -- Cold Spring Harbor : Cold Spring Harbor Laboratory Press, 2022. – (58.174212/E78/4th ed.)

Contents

Foreword, xi
Preface, xiii
Praise for the Previous Editions of Essentials of Glycobiology, xv
Contributors, xix
Editors of Earlier Editions, xxiii
Consultant Reviewers, xxiv
Classic Books and Monographs, xxv
Abbreviations, xxvii
GENERAL PRINCIPLES
1  Historical Background and Overview, 1
2  Monosaccharide Diversity, 21
3  Oligosaccharides and Polysaccharides, 33
4  Cellular Organization of Glycosylation, 43
5  Glycosylation Precursors, 53
6  Glycosyltransferases and Glycan-Processing Enzymes, 67
7  Biological Functions of Glycans, 79
8  A Genomic View of Glycobiology, 93
STRUCTURE AND BIOSYNTHESIS
9  N-Glycans, 103
10  O-GalNAc Glycans, 117
11  Glycosphingolipids, 129
12  Glycosylphosphatidylinositol Anchors, 141
13  Other Classes of Eukaryotic Glycans, 155
14  Structures Common to Different Glycans, 165
15  Sialic Acids and Other Nonulosonic Acids, 185
16  Hyaluronan, 205
17  Proteoglycans and Sulfated Glycosaminoglycans, 217
18  Nucleocytoplasmic Glycosylation, 233
19  The O-GlcNAc Modification, 251
GLYCANS IN EVOLUTION AND DEVELOPMENT
20  Evolution of Glycan Diversity, 265
21  Eubacteria, 279
22  Archaea, 297
23  Fungi, 307
24  Viridiplantae and Algae, 319
2S  Nematoda, 335
26  Arthropoda, 349
27  Deuterostomes, 365
GLYCAN-BINDING PROTEINS
28  Discovery and Classification of Glycan-Binding Proteins, 375
29  Principles of Glycan Recognition, 387
30  Structural Biology of Glycan Recognition, 403
31  R-Type Lectins, 419
32  L-Type Lectins, 431
33  P-Type Lectins, 443
34  C-Type Lectins, 455
35  I-Type Lectins, 475
36  Galectins, 491
37  Microbial Lectins: Hemagglutinins, Adhesins, and Toxins, 505
38  Proteins That Bind Sulfated Glycosaminoglycans, 517
GLYCANS IN PHYSIOLOGY AND DISEASE
39  Glycans in Glycoprotein Quality Control, 529
40  Free Glycans as Bioactive Molecules, 539
41  Glycans in Systemic Physiology, 549
42  Bacterial and Viral Infections, 555
43  Parasitic Infections, 569
44  Genetic Disorders of Glycan Degradation, 583
45  Congenital Disorders of Glycosylation, 599
46  Glycans in Acquired Human Diseases, 615
47  Glycosylation Changes in Cancer, 631
METHODS AND APPLICATIONS
48  Glycan-Recognizing Probes as Tools, 645
49  Glycosylation Mutants of Cultured Mammalian Cells, 663
50  Structural Analysis of Glycans, 675
51  Glycomics and Glycoproteomics, 689
52  Glycoinformatics, 705
53  Chemical Synthesis of Glycans and Glycoconjugates, 719
54  Chemoenzymatic Synthesis of Glycans and Glycoconjugates, 729
55  Chemical Tools for Inhibiting Glycosylation, 739
56  Glycosylation Engineering 753
57  Glycans in Biotechnology and the Pharmaceutical Industry, 771
58  Glycans in Nanotechnology, 785
59  Glycans in Bioenergy and Materials Science, 797
60  Future Directions in Glycosciences, 805
Glossary, 815
Study Guide, 823
Index, 835