Autophagy in health and disease / edited by Aitziber Buqué Martinez , Lorenzo Galluzzi. -- Cambridge, MA : Academic Press, an imprint of Elsevier, 2020. – (58.178/P964/v.172)

Contents

Contributors
Preface--Autophagy: An old mechanism with new challenges ahead
1. Nucleophagy mediators and mechanisms
      1. Introduction: General and selective autophagy
      2. Conclusion and future perspectives
      Acknowledgments
      Conflict of interest
      References
2. Scaffold proteins in bulk and selective autophagy
      1. Introduction
      2. Scaffold proteins during autophagy initiation
      3. The role of scaffold proteins in phagophore expansion
      4. The role of scaffold proteins in the fusion of autophagosomes with the lyric compartment
      5. Autophagy scaffold proteins in disease
      6. Concluding remarks
      Acknowledgments
      References
3. A global view of the miRNA-mitophagy connexion
      1. Introduction
      2. Mammalian key proteins in mitophagy
      3. MicroRNAs
      4. Mammalian mitophagy regulation by microRNAs
      5. interconnecting microRNAs and mitophagy to favor new therapeutic approaches for neurodegenerative diseases and cancers
      6. Conclusions
      Acknowledgments
      References
4. Crosstalk between autophagy and apoptosis" Mechanisms and therapeutic implications
      1. Autophagy in mammalian cells
      2. Autophagy regulation of apoptosis
      3. What experimental data are needed to understand how autophagy controls a different cellular process?
      4. Autophagy regulation of cancer drug-induced apoptosis
      5. Implications for cancer therapy
      Acknowledgment
      References
  5. Autophagy in immunity
      1. ATG product supported cellular pathways
      2. Atg proteins in cell intrinsic immunity
      3. Regulation of innate immunity by Atg proteins
      4. Influence of Atg proteins on adaptive immunity
      5. Considerations regarding the net outcome of autophagy regulation on immune responses
      Acknowledgments
      References
6. Autophagy in cardiovascular health and disease
      1. Introduction
      2. Autophagy in cardiovascular health
      3. Autophagy in cardiovascular disease
     4. Concluding remarks
      Acknowledgments
      References
7. Autophagy in kidney disease: Advances and therapeutic potential
      1. introduction
      2. Autophagy in acute kidney injury
   3. Autophagy in chronic kidney disease
      4. Potential therapeutic approaches and clinical applications
      5. Concluding remarks
      Acknowledgments
      Disclosure statement
      References
 8. Autophagy in chronic lung disease
      1. Introduction
      2. Autophagy and the lung
      3. Obstructive lung diseases
      4. Pulmonary vascular disease
      5. Restrictive lung disease
      6. Concluding remarks
      Acknowledgments
      Disclosure statement
      References
 9. Autophagy in motor neuron diseases
      1. Autophagy in amyotrophic lateral sclerosis (ALS)
      2. Autophagy in spinal muscular atrophy (SMA)
      3. Autophagy in spinal and bulbar muscular atrophy (SBMA)
      4. Autophagy in other motor neuron diseases
      5. Autophagy regulation of membraneless organelles in MNDs
      6. Concluding remarks and future directions
      Acknowledgments
      References
10. Strategies employed by viruses to manipulate autophagy
      1. The mechanisms of autophagy
      2. The signaling cascades regulating autophagy
      3. The physiological functions of autophagy
      4. Autophagy and viruses
      5. Strategies to inhibit autophagy
      6. Strategies to trigger autophagy
      7. Conclusions and perspectives
      Acknowledgments
      References
 11. Crinophagy mechanisms and its potential role in human health and disease
      1. The various forms of autophagy
      2. Pre-requisites for autophagic degradation
      3. Crinophagy: A nearly forgotten cell biological pathway
      4. Molecular background of secretory granule-lysosome fusion in Drosophila melanogaster
      5. Current methods to analyze secretory granule-lysosome fusion
      6. Medical relevance and pathology
      7. Future perspectives
      8. Vocabulary
      Acknowledgments
      References
12. Autophagy role in environmental pollutants exposure
      1. Introduction
     2. Autophagy molecular mechanism
      3. Autophagy at the intersection between cell protection and cell death
      4. Autophagy and environmental pollutants
      5. Conclusions
      Acknowledgments
      References
13. Genetic defects of autophagy linked to disease
      1. Autophagy as a mechanism for intracellular homeostasis
      2. Diseases caused by genetic mutations in core ATG genes
      3. Disease caused by mutations in genes associated with autophagy
      4. Diseases caused by mutations in autophagic receptor genes
      5. Conclusions
      Acknowledgments
      References
14. C. elegans to model autophagy-related human disorders
      1. Introduction
      2. Conserved functions and regulatory mechanisms
      3. Tools for autophagy detection and flux analyses
      4. Nematode models of autophagy-related human pathologies
      5. Future challenges and opportunities
      References
15. Drosophila as a model to understand autophagy deregulation in human disorders
      1. Introduction
      2. Autophagy in tumorigenesis
      3. Neurodegenerative diseases
      4. Lysosomal diseases
      5. Infectious disease
      6. Using Drosophila models for drug discovery
      7. Conclusion
      Acknowledgments
      Conflict of interest
      References
Index