Epigenetics / edited by Subhash C. Pandey. -- Cambridge, MA : Academic Press, 2021. – (59.59/P526/v.156)

Contents

Contributors
Preface
1. Histone modifications, DNA methylation, and the epigenetic code of alcohol use disorder
    1. Introduction
    2. Epigenetics and gene expression
    3. Histone acetylation mechanisms in alcohol use and dependence
    4. Histone methylation mechanisms in alcohol abuse and dependence
    5. DNA methylation and gene expression
    6. DNA methylation mechanisms in alcohol abuse and dependence
   7. New technologies for studying histone posttranslational modifications and epigenetic regulation
    8. Conclusions
    Acknowledgment and disclosure
    Conflict of interest
    References
2. Epigenetic and non-coding regulation of alcohol abuse and addiction
    1. Introduction
    2. Genetics, epigenetics, and epigenomics
    3. Histones and post-translational modifications
    4. Non-coding sequences
    5. Methylation, acetylation, and ubiquitination
    6. The role of non-coding RNAs in addiction
    7. Conclusion and future directions
    Acknowledgment
    Disclosure
    References
3. Epigenetic mechanisms underlying stress-induced depression
     1. Introduction
     2. Methods to induce depressive-like behavior in rodents
     3. Tests of depressive-like behavior in rodents
     4. Histone acetylation and deacetylation in depressive-like behavior
     5. Histone methylation and demethylation in MDD
     6. DNA methylation and demethylation in MDD
     7. Histone modifications, DNA methylation, inflammation, and MDD
     8. Sex differences in epigenetic mechanisms underlying depression
     9. Conclusions
     Acknowledgment
     References
4. Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics
    1. Introduction
    2. Epigenetic actors of DNA methylation
    3. Environmental stress: A trigger of epigenetic reprogramming
    4. DNA methylation impairments in major depressive disorder
    5. Alcohol use disorder: A DNA methylation reprogramming
    6. Evidence for epigenetic alterations in post-traumatic stress disorder
    7. Conclusion
    Acknowledgment
    References
5. Prenatal stress induced chromatin remodeling and risk of psychopathology in adulthood
    1. Introduction
    2. Prenatal stress is associated with psychiatric disorders in adult offspring
    3. Epigenetics of psychotic disorders
    4. Prenatal stress animal models of psychiatric disorders and epigenetic mechanisms
    5. Conclusions
    Acknowledgment
    References
    Further reading
6. Exposure to drugs of abuse induce effects that persist across generations
    1. Introduction
    2. Overview of epigenetics
    3. Drug-induced epigenetic modifications
    4. Overview of transgenerational effects of substance abuse
    5. Ethanol
    6. Cocaine
    7. Nicotine
    8. Cannabinoids
    9. Opiates
    10. Conclusions and future directions
    Acknowledgment
    References