Allosteric modulation of G protein-coupled receptors / edited by Robert B Laprairie. -- London : Academic Press, 2022. – (58.17421/A441)

Contents

List of contributors
About the editor
Preface
Special thanks
Pedagogical foundation and features
About "Allosteric modulation of the G protein-coupled receptors"
SECTION 1 Critical concepts
1. Introduction
2. G protein-coupled receptor (GPCR)-dependent transduction
SECTION 2 Important considerations and unique allosteric interactions
3. Computer modeling of allosteric modulators at G protein-coupled receptors
4. Ions as GPCR allosteric modulators
5. Protein-protein allosteric effects on cannabinoid receptor heteromer signaling
6. Allosteric ligands to study medium and long chain free fatty acid GPCRs
SECTION 3 Methods for advancing the field
7. Moving from cells to animals: challenges of studying allosteric modulators in vivo
8. Exploring the use of intracellular and extracellular allosteric modulators to understand GPCR signaling
9. Allosteric modulation of tethered ligand-activated G protein-coupled receptors
Index