Advances in genetics. Volume 105 / edited by Dhavendra Kumar. -- Cambridge, MA : Academic Press, 2020. – (58.14/A244/v.105)

Contents

Contributors
Preface
1. Pathogen and host genetics underpinning cryptococcal disease
    1. Introduction
    2. Cryptococcus spp. genetics and genomics
    3. Cryptococcosis
    Acknowledgments
    References
2. Role of RNA-interacting proteins in modulating plant-microbe interactions
    1. Introduction
    2. Crossing barriers: HIGS into action
    3. RNA-interacting proteins at the verge of plant-pathogen interaction
    4. RNA chaperone-sRNA interplay in host-microbe interaction
    5. Pathogenic sRNAs to impede host defense
    6. sRNAs on the move: Mechanistic insights into cross-kingdom sRNA movement
    7. Concluding remarks
    Acknowledgments
    References
3. FMRP ribonucleoprotein complexes and RNA homeostasis
    1. Introduction
    2. FMR1-associated clinical conditions
    3. FMRP is a synaptic regulator
    4. FMRP in ribonucleoprotein (RNP) complexes
    5. Concluding remarks
    Acknowledgments
    References
4. "Electrifying dysmorphology": Potassium channelopathies causing dysmorphic syndromes
    1. Introduction
    2. Potassium channel structure and function
    3. Andersen-Tawil syndrome
    4. Bauer-Tartaglia (FHEIG) syndrome
    5. Birk-Barel syndrome (BBS)
    6. Canto syndrome
    7. Keppen-Lubinsky syndrome (KLS)
    8. Temple-Baraitser syndrome O-BS)
    9. Zimmermann-Laband syndrome (ZLS)
    10. Conclusions
    Acknowledgments
    References
5. Recent advances in oomycete genomics
    1. The oomycetes
    2. Oomycete genomes
    3. Oomycete phylogenomics
    4. Oomycete mitochondrial genomes
    5. The impact of horizontal gene transfer on oomycete evolution
    6. Genome mining for oomycete effectors
    7. Oomycete OMICS studies
    8. Tools for oomycete genomics
    9. Oomycetes in the post-genomic era
    10. Conclusions and future outlook
    Acknowledgments
    References
6. Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance
    1. Introduction
    2. History of novel antibiotic discovery
    3. Metabolite biosynthesizing microbes
    4. Antibiotics classification and their mode of actions
    5. Antibiotic resistance and evolution of superbugs
    6. Problem of antimicrobial resistance
    7. Foundation of antibiotic era
    8. Qualities to qualify as an antibiotic
    9. Antibiotics developmental pipeline and causes of discovery void
    10. Maintenance of antibiotics pipeline
    11. Metabolites detection
    12. Metabolites profiling
    13. Characteristics of versatile surrogate chassis hosts
    14. Silent/cryptic gene clusters, their roles and significance
    15. Secondary metabolic cluster (presence of biosynthetic, resistance and transporters)
    16. Complex cascade regulation of antibiotic biosynthesis in actinomycetes (Nikkomycin biosynthetic cluster as an example)
    17. Classical approaches for detection of novel antibiotics
    18. Bioactivity analysis of novel antimicrobial compounds
    19. Strategies for prediction, analysis and activation of BGC
    20. Alternative approaches to conventional antibiotics
    21. Perspectives, challenges and conclusions
    References
7. Application of yeast to studying amyloid and prion diseases
    1. Introduction
    2. Overview of yeast prions
    3. Yeast models for polyglutamine aggregation
    4. Yeast models for aggregation of (z-synuclein, associated with Parkinson's disease (PD)
    5. Yeast models for amyloid proteins associated with Alzheimer's disease (AD) and tauopathies
    6. Yeast models for aggregation of mammalian prion protein (PrP)
    7. Yeast models for proteins associated with amyotrophic lateral sclerosis (ALS)
    8. Aggregation of transthyretin in yeast
    9. Yeast assay for amyloid nucleation by mammalian proteins
    10. Conclusions and future directions
    Acknowledgments
    References