Advances in genetics. Volume 107 / edited by Dhavendra Kumar. -- Cambridge, MA : Academic Press, 2021. – (58.14/A244/v.107)

Contents

Contributors
Preface
1. Advances in asthma genetics
    1. Introduction
    2. Asthma genetics
    3. Epigenetics in asthma
    4. Asthma and the microbiome
    5. Pharmacogenomics of asthma
    6. Precision medicine in asthma
    References
2. Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans
    1. Nutritional control of development in C. elegans--Why do we care?
    2. C. elegans postembryonic development
    3. Methods to measure developmental timing in C. elegans
    4. Nutrient sensing pathways in C. elegans
    5. Food deprivation provokes arrest at the L1 stage
    6. Larval arrest at other stages
    7. Diet-induced changes in developmental speed
    Acknowledgments
    References
3. Diverse role of phytic acid in plants and approaches to develop low-phytate grains to enhance bioavailability of micronutrients
    1. Introduction
    2. Phytic acid structure, biosynthesis, and accumulation
    3. Diverse roles of phytic acid
    4. Antinutritional properties of phytic acid
    5. Conventional and molecular breeding for low phytic acid lines
    6. Transgene-based approaches to produce zero phytate grains
    7. Conclusions
    Acknowledgments
    References
4. Founder variants and population genomes--Toward precision medicine
    1. Introduction
    2. Resources cataloging founder variants
    3. Population databases of human genetic variants
    4. Approaches for detection of founder variants
    5. Founder variations and genetic diseases across the world
    6. Implications of founder mutations in public health
    7. Challenges and future directions
    8. Conclusions
    References
5. Genomic perspectives on the circadian clock hypothesis of psychiatric disorders
    1. Introduction: Circadian clocks and their role in mental health and psychiatric disorders
    2. Phenotypic evidence for connections between circadian rhythms and psychiatric disorders
    3. Predictions of circadian clock genes as candidate genes for psychiatric disorders
    4. GWAS analysis of circadian phenotypes and psychiatric disorders, and the search for a connection
    5. Conclusions
    Acknowledgments
    References
6. Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery
    1. Introduction
    2. Chemistry of fungal SMs
    3. Drug discovery from fungi
    4. Genomics of fungal secondary metabolic dusters
    References