Stem cells and Covid-19 / edited by Chandra P. Sharma, Devendra K. Agrawal, Finosh G. Thankam. -- london : Academic Press, 2022. – (63.9451/S824)

Contents

Contributors
Preface
Chapter 1 Introduction
Chapter 2 Characteristics and immunobiology of COVID-19
  Introduction
  Structure and etiology
  Pathology of infection
  Immunology and signaling mechanisms
  Cytokine storm
  Current treatment approaches
  Translational avenues and perspectives
  Acknowledgments
  Conflict of Interests
  References
Chapter 3 An insight into the molecular mechanisms of mesenchymal stem cells and their translational approaches to combat COVID-19
  Introduction and background
  Pathophysiology of SARS-CoV-2
  Conventional and contemporary translational approaches to combat COVID-19
  Stem cell therapy as a novel translation approach against the COVID-19 pandemic
  Conclusion and outlook for the future
  Acknowledgment
  Conflict of interest
  Financial support
  References
Chapter 4 Inflammatory multisystem syndrome in COVID-19: Insights on off-target organ system in susceptible and recovering population
  Introduction
  Antigen processing and immune responses in COVID-19
  Cytokine storm
  Inflammation in COVID-19
  Respiratory system failure
  Cardiovascular manifestations in COVID-19
  Neurological and renal manifestation of COVID-19
  GI tract manifestations
  Conclusion
  Acknowledgment
  References
Chapter 5 Cytokine storm and stem cell activation in unveiling potential targets for diagnosis and therapy
  Introduction
  Cytokine storms
  Cytokine storms in viral respiratory infections
  Cytokine storms and stem cells
  Conclusion
  Acknowledgments
  References
Chapter 6 Mesenchymal stem cells: Novel avenues in combating COVID-19
  Introduction
  Alveolar cell and SARS-COVID-19
  Cytokine storm
  The reason behind using mesenchymal stem cells
  Conclusion
  References
Chapter 7 Immunomodulatory properties of mesenchymal stem cells and hematopoietic stem cells--Potential therapeutic target for COVID-19
  Introduction
  MSC as a cellular therapy
  Hematopoietic stem cells
  Translational potential of MSCs
  Conclusion
  Acknowledgments
  References
Chapter 8 COVID-19 and acute myocardial injury: Stem cell driven tissue remodeling in COVID-19 infection
  Introduction
  COVID-19: Etiology, transmission, structure, and pathophysiology
  COVID-19-CVD comorbidity
  Stem cells in cardiac remodeling
  ACE2 signaling and cardiac pathology COVID-19 infection
  Stem cell activation and signaling in ACE2 upregulation
  Cytokine surge and stem cell activation in MI
  Sheddases' response in cardiac stem cell differentiation (major focus to TMPRSS2, CTSL, and ADAM17)
  Perspectives in COVID-19 and cardiac responses
  Translational avenues and future
  References
Chapter 9 Stem cell-driven tissue regeneration as treatment for COVID-19
  Introduction
  Management of COVID-19 by stem cells
  Stem cell activation during pathology
  Growth factors as a vital target
  COVID-19 clinical trials
  Summary and significance
  References
Chapter 10 Stem cell transplantation for COVID-19 management: Translational possibilities and future
  Introduction
  Sources of stem cells
  Use of different types of stem cells in translational research
 Current COVID-19 related clinical trials using stem cells
 Challenges of using stem cells and future perspective
 Conclusion
 References
Chapter 11 Therapeutic scale stem cell-derived exosomes for COVID-19: Models--Validation, management, and strategies
  Introduction to Covid-19
  Pathophysiology
  Interventions
  Stern cell population/product condition addressed outcome
  Exosome for management
  Exosome challenges
  References
Chapter 12 Current strategies and future perspectives in COVID-19 therapy
  Introduction
  COVID-19: An overview
  COVID-19 diagnosis
  Current treatment strategies
  Future perspectives
  Conclusion
  Acknowledgments
  References
Index