Advances in immunology. Volume 146 / edited by Frederick W. Alt. -- Amsterdam : Elsevier, c2020. – (58.691 /A244 /v.146)

Contents

Contributors

1. Transcriptional regulation of natural killer cell development and maturation

    1. Overview of natural killer cells

    2. Natural killer cell development and maturation

    3. Transcriptional control of natural killer cell development and maturation

    4. Conclusions

    References

2. Friend or foe? Lactobacillus in the context of autoimmune disease

    1. Introduction: Influences on host-microbiota interactions in autoimmunity

    2. Lactobacilli in autoimmune and neurologic diseases

    3. Lactobacillus johnsonii and L. reuteri as paradigms

    4. The gut barrier as a decisive factor for translocation of enterococci and lactobacilli

    5. The influence of diet on L. reuteri growth and translocation

    6. A variety of metabolites of L. reuteri influence host health

    7. Conclusion: Strain-specific effects of lactobacilli have implications for translational medicine

    Acknowledgments

    Declaration of interest

    References

3. Unraveling the mysteries of plasma cells

    1. The discovery of plasma cells

    2. The generation of plasma cells--The big three: Blimp-1/Xbp-1/IRF-4

    3. The niche concept--Who wants to live forever

    4. Metabolism and autophagy--From glucose to glycosylation

    5. Regulatory functions of plasma cells

    6. Identification of plasma cell subsets

    7. Depletion of plasma cells--Current regimes and their limitations

    8. Perspectives

    References

4. Homeostatic and pathogenic roles of PI3Kδ in the human immune system

    1. Overview of phosphatidylinositol 3 kinases

    2. Role of PI3Kδ in the immune system

    3. Summary

    Acknowledgments

    References