International review of cell and molecular biology. Volume 349, Immunobiology of dendritic cells. Part B / edited by Claire Lhuillier, Lorenzo Galluzzi. -- Cambridge, MA : Academic Press, 2019. – (58.15 /I61 /v.349) |
Contents
Contributors
Preface: Dendritic cells: Master regulators
of innate and adaptive immunity
1.
Origin and development of classical dendritic cells
1. Introduction
2. Classical dendritic cell subsets
3. Growth factors dependence of classical dendritic cell subsets
4. Bone marrow progenitors for classical dendritic cells
5. Circulating precursors for classical dendritic cells
6. Peripheral niches
7. Transcriptional regulation of classical dendritic cell development
8. Conclusion and open questions
Acknowledgment
References
Further reading
2.
Transcriptional control of dendritic cell development and functions
1. Introduction
2. The unique functions of DCs
3. Overview about antigen uptake, processing and presentation by DCs
4. Phenotypical characterization of cDCs
and pDCs
5. Identification and functional specialization of the cDC1 subset
6. Identification and functional specialization of the cDC2 subset
7. cDC1 and cDC2 and the induction and maintenance of tolerance
8. Identification and functional specialization of pDCs
9. Origin, identification and functional specialization of Langerhans
cells
10. Identification and functional specialization of MoDCs
11. Phenotypical characterization, functional specialization, and
presence of DC subsets in human tissues
12. The development of early DC progenitors within the bone marrow
13. Crucial factors for DE development: Flt3 and Flt3L, GM-CSF and GM-CSFR
14. Transcriptional regulation of DC differentiation and function
15. Impact of post-transcriptional regulation by microRNAs
16. Epigenetic regulation of DCs
17. Conclusions
Acknowledgments
Statement
References
3.
The impact of endoplasmic reticulum stress responses in dendritic cell
immunobiology
1. A brief introduction to dendritic cell biology
2. ER stress responses in DCs
3. Concluding remarks
Acknowledgments
Competing interest
References
4.
The versatile plasmacytoid dendritic cell: Function, heterogeneity, and
plasticity
1. Introduction
2. Functional diversity of plasmacytoid dendritic cells
3. Sources of pDC functional diversity: Developmentally encoded subsets versus
environmentally mediated plasticity
4. Concluding remarks
Acknowledgments
References
5.
Dendritic cell extracellular vesicles
1. Introduction
2. Molecular identity of dendritic cell-derived extracellular vesicles
3. Diversity of extracellular vesicles from dendritic cells
4. The journey of an extracellular vesicle: From its biogenesis to its
final destination in the target cell
5. Role of dendritic cell-derived extracellular vesicles as modulators
of immune responses
6. Clinical application of dendritic cell-derived extracellular vesicles
7. Concluding remarks and perspectives
Acknowledgments
References
6. Ex
vivo dendritic cell generation--A critical comparison of current approaches
1. Cytokine signals
2. Physiological signals for DC differentiation
3. Gene engineering tools
4. Clinical trials of DC-based vaccines
5. Concluding remarks
Conflict of interest
References