Introduction to peptide science / Ian W. Hamley. -- Hoboken, NJ : Wiley, 2020. – (58.174213 /H223)

Contents

Preface

1    Basic Properties

     1.1   Introduction

     1.2   Properties of Amino Acids

     1.3   The Peptide Bond

     1.4   Secondary Structures

     1.5   Peptide Structure and Conformation Characterization Methods

     1.6   Peptide Databases and Web Software

     Bibliography

2    Synthesis

     2.1   Introduction

     2.2   Solid-Phase Peptide Synthesis

     2.3   Solution-Phase Peptide Synthesis

     2.4   Methods to Prepare Longer Peptides

     2.5   Peptide Library Synthesis

     2.6   Synthesis of Cyclic Peptides

    2.7   Peptidomimetics

     2.8   Post-Translational Modifications

     2.9   Lipidation

     2.10  Glycosylation

     2.11  Polypeptide Polymers and Conjugates of Peptides and Polymers

    2.12  Non-Ribosomal Peptide Synthesis

     2.13  Purification and Analysis Methods

    Bibliography

3    Amyloid and Other Peptide Aggregate Structures

     3.1   Introduction

     3.2   Amyloid

     3.3   Amyloid 13

     3.4   Mechanisms and Kinetics of Amyloid Aggregation

     3.5   Toxicity and Relevance to Disease

     3.6   Fibrillization of Small Peptides

     3.7   Biological Functional Amyloid and Bioengineering Applications of Amyloid Materials

     3.8   Fibrils From ~t-Helices

     3.9   Peptide Hydrogels and Tissue Scaffolds

     3.10  Peptide Nanotubes

     3.11  Peptide and Peptide Conjugate Assemblies

     3.12  Characterization Methods for Peptide Assemblies

     Bibliography

4    Antimicrobial and Cell-penetrating Peptides

     4.1   Introduction

     4.2   Bacterial Pathogens, Targets of Antibacterial Agents, and Antimicrobial Resistance Pathways

     4.3   Testing Antimicrobial Activity

     4.4   Bacterial Biofilms

     4.5   Design of Antimicrobial Peptides

     4.6   Classes of Antibacterial Peptides

     4.7   Antifungal Peptides

     4.8   Antiviral Peptides

     4.9   Antiparasitic Peptides

     4.10  Mechanisms of Activity

     4.11  Cell-Penetrating Peptides

     Bibliography

5    Peptide Hormones and Peptide Therapeutics

     5.1   Introduction

     5.2   General Principles of Peptide Therapeutics

     5.3   Peptide Hormones

     5.4   Neuropeptides and other Peptides In vivo

     5.5   Venom-Derived Peptides

     5.6   Anticancer Peptides

     5.7   Miscellaneous Peptide Therapeutics

     5.8   Cosmetic Peptides and Lipopeptides

     Bibliography

Index