Genomics / Lia Chappell, Sarah J Lindsay, Phil Jones, Julian Parkhill, Jonathon Roberts, Nancy Holroyd, Michael Spzak ; edited by Ann Fullick. -- Oxford : Oxford University Press, c2020. – (58.1483 /C467)

Contents

Preface

About the authors

Abbreviations

1 Rare diseases: a genomics perspective

      What is genomics?

      What is a rare disease?

      Current and emerging technologies

      Next steps: potential therapies and ethics

2 Cancer genomics

      The genetic origins of cancer

      Mutations and signatures

      How cancer develops

      Why don't we all have cancer?

      The cancer phenotype

      Genomics and drug discovery

3 Genomes and ethics

      People as patients

      People as consumers

      People as citizens

      Conclusions

4 Pathogen genomics

      How did we get here? A short history of pathogen genomics

      What are we doing here? What pathogen genomics tells us about pathogen biology

     Dating pathogens

      Programmed variation

      Metagenomics

      Where are we going? Real-world applications of pathogen genomics

5 Parasite genomics

      What is a parasite?

      What can genomics reveal?

      Current and emerging techniques

      Antigenic variation: now you see me, now you don't

      Using genomics to control the spread of parasitic diseases

      The arms race between medicine and parasites

      Keeping parasites in the lab

6 Human evolution

      Humans as great apes

      Human fossils and archaeology

      What changes made us human?

      Our expansion out of Africa

      From hunters and gatherers to farmers

7 Genomics: reading and writing genomes

      Reading DNA: a definition of sequencing

      Sequencing to reveal active genes

      Synthetic biology: writing entirely new genomes

Glossary

Index