Bioinformatics for diagnosis, prognosis and treatment of complex diseases / edited by Bairong Shen. -- Dordrecht : Springer, 2013. – (58.17115/B615)

Contents

Part I  Bioinformatics for Complex Diseases: The Basics

1   Molecular Diagnostic Techniques

2   Identifying Biomarkers with Differential Analysis

3   Identifying Driver Mutations in Cancer

4   Biomarker Discovery with Text Mining and Literature Based Discovery

5   Protein Binding Interfaces and Their Binding Hot Spot Prediction: A Survey

Part II  Network Based Diagnosis of Complex Diseases

6   Systems Biology Studies of Gene Network and Cell Signaling Pathway in Cancer Research

7   A Network Systems Approach to Identify Functional Epigenetic Drivers in Cancer

8   Identification of Cancer MicroRNA Biomarkers Based on miRNA-mRNA Network

Part III  Applications in Detection and Treatment of Complex Diseases

9   Ubiquitin and Ubiquitin-Like Conjugations in Complex Diseases: A Computational Perspective

10   Identification of Biomarkers for Pharmacological Activity

11   Network Biomarkers for Diagnosis and Prognosis of Human Prostate Cancer