Advances in protein chemistry and structural biology. Volume 115, DNA repair / edited by Rossen Donev. -- Cambridge, MA : Academic Press, 2019. – (58.17421/A244p/v.115)

Contents

Contributors

Preface

 1. DNA repair by photolyases

   1. Introduction

   2. Cryptochrome/photolyase protein family

   3. Conclusion

   Acknowledgment

   References

 2. TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair

   1. Introduction

 2. Composition, topology and structure of TFIIH

   3. The XPB translocase and the XPD helicase

   4. Regulatory core-TFIIH subunits

   5. Transcription regulation: The role of TFIIH

   6. TFIIH in nucleotide excision repair

   7. TFIIH, human diseases and next generation cancer therapies

   8. Conclusions

   Acknowledgments

   References

3. Chromatin control in double strand break repair

   1. DNA repair and chromatin

   2. Chromatin control of double strand break repair

   3. Chromatin in the temporal control of DSB repair

   4. Spatial control of DSB repair

   5. Concluding remarks

   Acknowledgments

   References

4. Controlling the balance between chromosome break repair pathways

   1. Reacting to chromosome breaks

   2. The DNA damage response

   3. The repair of DNA double strand breaks

   4. DNA end resection

   5. Local chromatin environment controls DNA end resection and homologous recombination

   6. The connection between the metabolism of RNA and DSB repair pathway choice

   7. Concluding remarks

   References

5. Targeting DNA repair in precision medicine

   1. Introduction

   2. DNA repair pathways

   3. DNA repair targets as therapeutic strategies

   4. DNA repair checkpoints

   5. Summary

   References

6. Replication stress: Driver and therapeutic target in genomically instable cancers

   1. Introduction

   2. DNA replication

   3. Replication stress

   4. How to deal with RS

   5. Targeting replication stress in cancer

   6. Concluding remarks

   Acknowledgments

   References

7. Claspin: From replication stress and DNA damage responses to cancer therapy

   1. Introduction

   2. Claspin, DNA replication, and replication stress

   3. Claspin and the DNA damage response

   4. Claspin as a target for chemo- and radio-sensitization

   5. Conclusions and perspectives

   Conflict of interest

   Funding

   References

8. cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy

   1. Melanoma: A growing problem

   2. Melanocortin 1 receptor (MC1R)

   3. Melanins

   4. Role of ultraviolet light in DNA damage

   5. Repair of DNA damage

   6. Intersection of melanocytes and NER

   Acknowledgments

   Conflicts of interest

   References

9. Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling

   1. Introduction

   2. DNA metabolic factors negatively regulate immune signaling

   3. Mechanisms of immune signaling regulation by DDR factors

   4. Consequences of defective DDR factors mediated immune signaling

   5. Conclusions

   Acknowledgments

   References

10. Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach

   1. Introduction

   2. Materials and methods

   3. Result

   4. Discussion

   5. Conclusion

   Acknowledgments

   Disclosure statement

   References

   Further reading

11. A computational model to predict the structural and functional consequences of missense mutations in O⁶-methylguanine DNA methyltransferase

   1. Introduction

   2. Materials and methods

   3. Results

   4. Discussion

   5. Conclusion

   Acknowledgments

   Disclosure statement

   References

   Further reading