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International review of cell and molecular biology. Volume 342, Biology of T cells. Part B / edited by Lorenzo Galluzzi, Nils-Petter Rudqvist. -- Amsterdam : Academic Press, 2019. – (58.15/I61/v.342) |
Contents
Contributors
Preface. T Cells: Friends and Foes
1. Stimulating T Cells Against Cancer With Agonist Immunostimulatory Monoclonal Antibodies
1. Introduction
2. CD137
3. GITR
4. OX40
5. CD27
6. Emerging Agonists: ICOS and CD40
7. CD28 Superagonist as a Cautionary Tale
8. Conclusions
References
2. T Cells and Regulated Cell Death: Kill or Be Killed
1. Introduction
2. Cell Death Pathways in T Cells
3. T Cell-Mediated Cell Death
4. Concluding Remarks
Acknowledgments
References
3. Macrophages: Their Untold Story in T Cell Activation and Function
1. Introduction
2. Macrophages as Efficient APCs
3. Cross-Presentation and TCR Engagement of the MHC Serves as Signal 1
4. Signal 2: Costimulatory and Inhibitory Receptors on Macrophages
5. Signal 3: Environmental Cytokine Production Directs T Cell Differentiation and Effector Function
6. The Role of Macrophages on T Cell Inhibition and Exhaustion
7. Tumor-Associated Macrophages
Acknowledgments
References
4. Metabolism of T Lymphocytes in Health and Disease
1. Introduction
2. Metabolic Pathways: An Overview
3. T Cells Possess a Specific Metabolic Profile That Is Crucial for Survival and Function
4. Metabolic Pathways to Maintain T-Cell Homeostasis
5. Metabolic Reprogramming upon Engagement of Effector T Cells
6. Immunometabolism of Regulatory T Cells
7. Metabolic Reconfiguration in T-Cell Memory and Longevity
8. Tumor Microenvironment Shapes T-Cell Metabolism and Function
9. T-Cell Metabolism in Autoimmunity
10. Conclusion
References
5. Cancer Immunosurveillance by T Cells
1. What Is Cancer Immunosurveillance?
2. What Role Do T-Cell Subsets Play in Cancer Immunosurveillance?
3. Immune Checkpoints and Immunosurveillance--A Delicate Balance
4. What Role Do Tumor Antigens Play in Cancer Immunosurveillance?
5. Conclusions
References
6. T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders
1. Introduction
2. Respiratory Virus Disorders
3. Viral Gastroenteritis Disorders
4. Exanthematous Viral Disorders
5. Hepatic Viral Disorders
6. Neurologic Viral Disorders
7. Hemorrhagic Fever Viral Disorders
8. Perspectives
Acknowledgments
Contributions
References
7. In Silico Methods for Studying T Cell Biology
1. Introduction
2. Cytometry With Time of Flight
3. Immune Infiltration Analysis From Transcriptomic Data
4. Inferring TCR Clonotypes From RNASeq Data
5. T Cell Receptor Sequencing
6. Peptide/MHC Dynamics and Immunogenicity Predictions
7. Mathematical Modeling of T Cell Dynamics
8. Databases for Studying T Cells Biology
9. Conclusions
References
