Clinical and statistical considerations in personalized medicine / edited by Claudio Carini, Sandeep Menon, Mark Chang. -- Boca Raton : CRC Press/Taylor & Francis, 2014. – (63.4/C641)

Contents

Preface

Editors

Contributors

1. Biomarkers for Drug Development: The Time Is Now!

2. RNAi Screens: Triumphs and Tribulations

3. Current Advances in Epigenetics

4. Biomarkers and Precision Medicine: The Case of Rare Diseases

5. Biomarker-Informed Adaptive Design

6. Fitting the Dose: Adaptive Staggered Dose Design

7. Evidence-Based Adaptive Statistical Decision and Design Strategies for Maximizing the Efficiency of Clinical Oncology Development Programs with Predictive Biomarkers

8. Biomarker Identification in Clinical Trials

9. Multiplicity in Pharmacogenomics

10. Patient-Reported Outcomes in Personalized Medicine

11. Regulatory Issues in Use of Biomarkers in Drug Development

Index