Omics in clinical practice : genomics, pharmacogenomics, proteomics, and transcriptomics in clinical research / edited by Yu Liu. -- Toronto : Apple Academic Press, c2014. – (63.141/O55)

Contents

Acknowledgment and How to Cite

List of Contributors

Introduction

Part I: Omics and Human Disease

1.  Comparative Mitochondrial Proteomics: Perspective in Human Diseases

2.  Studies of Complex Biological Systems with Applications to Molecular Medicine: The Need to Integrate Transcriptomic and Proteomic Approaches

3.  Next Generation Sequencing in Cancer Research and Clinical Application

4.  Scientific Challenges and Implementation Barriers to Translation of Pharmacogenomics in Clinical Practice

Part II: Translational and Personalized Medicine

5.  Clinical Proteomics and OMICS Clues Useful in Translational Medicine Research

6.  Genomes2Drugs: Identifies Target Proteins and Lead Drugs from Proteome Data

Part III: Molecular and Genetic Markers

7.  Pitfalls and Limitations in Translation from Biomarker Discovery to Clinical Utility in Predictive and Personalised Medicine  179

8.  How Bioinformatics Influences Health Informatics: Usage of Biomolecular Sequences, Expression Profiles, and Automated Microscopic Image Analyses for Clinical Needs and Public Health

9.  Application of "omics" to Prion Biomarker Discovery

Part IV: Omits and Pathogens

10.  Insights from Genomics into Bacterial Pathogen Populations

11.  High Throughput Sequencing and Proteomics to Identify Immunogenic Proteins of a New Pathogen: The Dirty Genome Approach

12.  Coronavirus Genomics and Bioinformatics Analysis

Part V: Companion Diagnostics

13.  Applications of Next-Generation Sequencing Technologies to Diagnostic Virology

14.  Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture

Author Notes

Index