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Statistical genomics : methods and protocols / edited by Ewy Mathe, Sean Davis. -- New York : Humana Press, 2016. – (58.1481057/S797)

Contents

PART I  GROUNDWORK

1  Overview of Sequence Data Formats

2  Integrative Exploratory Analysis of Two or More Genomic Datasets

3  Study Design for Sequencing Studies

4  Genomic Annotation Resources in R/Bioconductor

PART II  PUBLIC GENOMIC DATA

5  The Gene Expression Omnibus Database

6  A Practical Guide to The Cancer Genome Atlas (TCGA)

PART III  APPLICATIONS

7  Working with Oligonucleotide Arrays

8  Meta-Analysis in Gene Expression Studies

9  Practical Analysis of Genome Contact Interaction Experiments

10  Quantitative Comparison of Large-Scale DNA Enrichment Sequencing Data

11  Variant Calling From Next Generation Sequence Data

12  Genome-Scale Analysis of Cell-Specific Regulatory Codes Using Nuclear Enzymes

PART IV Tools

13  NGS-QC Generator: A Quality Control System for ChIP-Seq and Related Deep Sequencing-Generated Datasets

14  Operating on Genomic Ranges Using BEDOPS

15  GMAP and GSNAP for Genomic Sequence Alignment: Enhancements to Speed, Accuracy, and Functionality

16  Visualizing Genomic Data Using Gviz and Bioconductor

17  Introducing Machine Learning Concepts with WEKA

18  Experimental Design and Power Calculation for RNA-seq Experiments

19  It's DE-licious: A Recipe for Differential Expression Analyses of RNA-seq Experiments Using Quasi-Likelihood Methods in edger

Index