International review of cell and molecular biology. volume 336 / edited by Lorenzo Galluzzi. -- Amsterdam : Academic Press, c2018. – (58.15/I61/v.336)

Contents

Contributors

1.  Membrane Trafficking in Autophagy

     1. Introduction

     2. Autophagy

     3. Membrane Trafficking

     4. Membrane Trafficking in Autophagosome Formation

     5. Autophagosome Maturation

     6. Autophagic Lysosome Reformation

     7. Noncanonical Autophagy

     8. Concluding Remarks

     Acknowledgments

     References

2.  Altered Metabolism of Leukemic Cells: New Therapeutic Opportunity

     1. Introduction

     2. Leukemia Classification

     3. Current Therapy

     4. Metabolism of Normal Hematopoietic vs Leukemic Cells

     5. Glucose Metabolism

     6. Oxidative Phosphorylation

     7. Tricarboxylic Acid Cycle: Isocitrate Dehydrogenase

     8. Lipid Metabolism

     9. Amino Acid Metabolism

     10. Concluding Remarks

     Acknowledgments

     References

3.  Profiling Celiac Disease-Related Transcriptional Changes

     1. Celiac Disease

     2. Microarray Studies

     3. RNA-Seq Studies

     4. miRNA Expression

     5. Disease Association and Function: Expression Quantitative Trait Loci

     6. CD Variants in Noncoding Regions

     References

4.  Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer

     1. Introduction

     2. IDOl in Immune Escape From T Ceil Immunity

     3. IDO1 in Inflammatory Programming: MDSC Development and Metastasis

     4. IDOl in Inflammatory Programming: Pathogenic Neovascularization and Metastasis

     5. IDO2 in B-Cell Inflamed States and Certain IDOl Functions: Connections and Questions

     6. TDO in Inflammatory Programming: Immune Escape, Anoikis Resistance, and Metastasis

     7. Lead Clinical Agents: Indoximod, Epacadostat, and Navoximod

     8. Other IDO/TDO Inhibitor Clinical Candidates

     Acknowledgments

     References

5.  Loss of Nuclear Envelope Integrity in Aging and Disease

     1. The Nuclear Envelope Safeguards Nuclear Compartmentalization

     2. Nuclear Envelope Erosion Compromises Transport Selectivity

     3. Nuclear Envelope Shedding Bypasses NPC Control

     4. Nuclear Envelope Rupture Triggers Abhorrent Nucleocytoplasmic Exchange

     5. Conclusion

     Acknowledgment

     References

6.  Mechanisms of Cortical Differentiation

     1. Introduction

     2. A Primer on Neocortical Anatomy

     3. Early Neocortical Development

     4. Control of Neocortical Neurogenesis

     5. Control of Neocortical Gliogenesis

     6. Conclusions and Future Perspectives

     Acknowledgments

     References

7.  New Insights Into Autophagy Dysfunction Related to Amyloid Beta Toxicity and Neuropathology in Alzheimer's Disease

     1. Introduction

     2. Autophagy and Its Machinery

     3. Aβ Biogenesis and AD-Related Toxicity

     4. Autophagy Dynamics and AD Pathogenesis

     5. APP and the Autophagosome: Site of Clearance and Site of Production

     6. Aβ Clearance and the Role of Autophagy in Aβ Homeostasis

     7. The Protein Signature of Autophagic Failure in AD

     8. Autophagy Control: Therapeutic Interventions in AD

     9. Summary and Future Directions

     Acknowledgments

     References