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The science of stem cells / Jonathan M.W. Slack. -- Hoboken, NJ : Wiley Blackwell, c2018. – (58.155/S631) |
Contents
Preface xi
About
the Companion Website xiii
1 What is a Stem Cell? 1
Stem
Cell Markers 3
Label-Retention 4
The
Niche 5
Asymmetric
Division and Differentiated Progeny
Clonogenicity
and Transplantation 6
In Vivo
Lineage Labeling 7
Conclusions 9
Further
Reading 10
2 Characterizing Cells 13
Histological
and Anatomical Methods 13
Other
Methods 19
Dividing
Cells 21
Further
Reading 30
3 Genetic Modification and the Labeling of Cell
Lineages 31
Introducing
Genes to Cells 31
Transgenic
Mice 38
Cell
Lineage 42
Further
Reading 47
4 Tissue Culture, Tissue Engineering and
Grafting 49
Simple
Tissue Culture 51
Complex
Tissue Culture 56
Grafting 60
Further
Reading 67
5 Early Mouse and Human Development 69
Gametogenesis 70
Fertilization 76
Early
Development 77
Further
Reading 90
6 Pluripotent Stem Cells 93
Mouse
Pluripotent Stem Cells 93
Human
Pluripotent Stem Cells 101
Pluripotent
Stem Cells from Postnatal Organisms 103
Applications
of Pluripotent Stem Cells 104
Further
Reading 105
7 Body Plan Formation 107
Embryological
Concepts 107
Key
Molecules Controlling Development 111
Body
Plan Formation 116
Further
Reading 123
8 Organogenesis
12,5
Nervous
System 12,5
Epidermis 134
Somitogenesis 137
The
Kidney 140
Blood
and Blood Vessels 142
The
Heart 145
The
Gut 146
Further
Reading 151
9 Cell Differentiation and Growth 155
Organs,
Tissues and Cell Types 155
Cell
Differentiation 158
Neurogenesis
and Gliogenesis 164
Skeletal
and Cardiac Muscle 171
Endodermal
Tissues 176
Further Reading 185
10 Stem Cells in the Body 189
The
Intestinal Epithelium 189
The
Epidermis 195
The
Hematopoietic System 204
Spermatogenesis 211
Further
Reading 213
11 Regeneration, Wound Healing and Cancer 217
Planarian
Regeneration 217
Amphibian
Limb Regeneration 220
Mesenchymal
Stem Cells 223
Mammalian
Wound Healing 225
Regeneration
and Repair 228
Cancer 228
Cancer
Stem Cells 233
Further
Reading 236
Index 239
