The biology and therapeutic application of mesenchymal cells. volume I / edited by Kerry Atkinson. -- Hoboken, New Jersey : John Wiley & Sons, c2017. – (58.155/B615/v.1)

Contents

Contributors, xxvii

Editor's Preface, xxxv

Section I: An overview of mesenchymal stem cells and mesenchymal stromal cells

1  The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome, 3

2  The nomenclature of mesenchymal stem cells and mesenchymal stromal cells, 8

Section II: The isolation and ex vivo expansion of mesenchymal stromal cells

3  The isolation and expansion of mesenchymal stromal cells from bone marrow, 13

4  The biology and clinical applications of mesenchymal stromal cells derived from human gestational tissues, 24

5  Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal origins and critical parameters for ex vivo expansion, 32

Section III: The cellular and molecular biology of mesenchymal stromal cells

6  Epigenetic regulation of mesenchymal stem/stromal cell growth and multipotentiality, 41

7  Biological changes in human mesenchymal stromal cells during monolayer culture, 58

8  The effect of three-dimensional aggregates on the biology of mesenchymal stromal cells, 75

9  Cell-cell signaling pathways that regulate mesenchymal stromal cell differentiation, 91

10  Regulation of mitochondrial transport in mesenchymal stromal cells, 104

11  The regulation of adipogenesis from adipose-derived stem/stromal cells, 114

12  Modulation of osteogenic differentiation in mesenchymal stromal cells, 131

13  The role of glycogen synthase kinase-3 inhibitors on bone remodeling, 148

14  Early molecular events during in vitro chondrogenesis, 167

15  The role of the extracellular matrix in the differentiation of mesenchymal stromal cells, 191

16  Effects of hypoxic culture on bone marrow multipotent mesenchymal stromal cells: from bench to bedside, 196

17  The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells, 208

18  The evolving concept of mesenchymal stromal cells in regenerative medicine: from cell differentiation to secretome, 222

19  The secretome of mesenchymal stem/stromal cells undergoing chondrogenic differentiation and those undergoing osteogenic or adipogenic differentiation, 236

20  Mesenchymal stromal cell extracellular vesicles/exosomes, 250

21  Role of tunneling nanotube crosstalk with distressed cardiomyocytes in controlling the heart repair potential of mesenchymal stromal cells, 264

22  The preferential homing of mesenchymal stromal cells to sites of inflammation, 286

23  The role of chemokines in mesenchymal stromal cell homing to sites of inflammation, including infarcted myocardium, 314

24  Live cell imaging and single cell tracking of mesenchymal stromal cells in vitro, 323

25  The role of mesenchymal stem/stromal cells in angiogenesis, 347

26  The relationship between mesenchymal stromal cells and endothelial cells, 366

27  The radioresistance of mesenchymal stromal cells and their potential role in the management of radiation injury, 391

28  The implications of multipotent mesenchymal stromal cells in tumor biology and therapy, 415

29  Mesenchymal stem/stromal cell therapy: mechanism of action and host response, 426

30  The differences between mesenchymal stromal cells and fibroblasts, 441

31  Derivation of mesenchymal stem/stromal cells from induced pluripotent stem cells, 456

32  The role of mesenchymal stem cells in hematopoiesis, 467

33  The modulatory effects of mesenchymal stromal cells on the innate immune system, 481

34  The modulatory effects of mesenchymal stromal cells on the adaptive immune system, 490

35  The role of mesenchymal stromal cells in the repair of acute organ injury, 496

36  The use of mesenchymal stromal cells in the treatment of diseases of the cornea, 524

37  The role of paracrine factors secreted by mesenchymal stromal cells in acute tissue injury, 544

38  Treatment of lung disuse by mesenchymal stromal cell extracellular vesicles, 553

39  Evaluating mesenchymal stem/stromal ceils for treatment of asthma and allergic rhinitis, 573

40  Stem cell therapies for Huntington's disease, 581

Section IV: The role of bioengineering in the therapeutic applications of mesenchymal stromal cells

41  Endometrial mesenchymal stromal cell and tissue engineering for pelvic organ prolapse repair, 601

42  Closed automated large-scale bioreactors' for manufacturing mesenchymal stromal cells for clinical use, 616

Section V: GMP manufacturing of mesenchymal stromal cells for clinical use

43  Current good manufacturing practice for the isolation and ex vivo expansion of mesenchymal stromal cells derived from term human placenta for use in clinical trials, 621

44  A comparison of high-tier regulatory documents pertaining to biologic drugs including mesenchymal stromal cells in Australia, Europe, and the USA using a manual documentary analysis, 628

Section VI: The therapeutic application of mesenchymal stromal cells

45  The use of mesenchymal stromal cells in acute and chronic heart disease, 647

46  The role of mesenchymal stem/stromal cells in the management of critical limb ischemia, 661

47  The role of mesenchymal stromal cells in the management of musculoskeletal disorders, 677

48  The potential role of bone marrow mesenchymal stromal cells in the treatment of ischemic stroke, 690

49  The role of mesenchymal stromal cells in spinal cord injury, 714

50  The role of mesenchymal stromal cells in the treatment of ulcerative colitis and Crohn's disease, 730

51  Mesenchymal stromal cells targeting kidney disease: benefits of a combined therapeutic approach, 754

52  The biology and potential clinical applications of mesenchymal stromal cells in diseases of the lung, 770

53  The role of mesenchymal stromal cells in diseases of the lung, 787

54  Mesenchymal stromal cells for the treatment of autoimmune diseases, 794

55  The role of mesenchymal stromal cells in bacterial infection, 814

56  The use of mesenchymal stromal cells in solid organ transplantation, 825

57  The role of mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation, 836

58  The role of mesenchymal stromal cells in the management of skin wounds, 841

59  The role of mesenchymal stromal cells in skin wound healing, 845

Section VII: Mesenchymal stromal cells as delivery vehicles for therapeutic agents

60  The role of mesenchymal stromal cells in human brain tumors, 859

61  Mesenchymal stromal cells as gene delivery vehicles to treat nonmalignant diseases, 873

62  Gene therapy for cancer using mesenchymal stromal cells, 892

Section VIII: The present and the future

63  Breaking news, 901

64  Reconciling the stem cell and paracrine paradigms of mesenchymal stem cell function, 912

Glossary, 927

Index, 949