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The biology and therapeutic application of mesenchymal cells. volume II / edited by Kerry Atkinson. -- Hoboken, New Jersey : John Wiley & Sons, c2017. – (58.155/B615/v.2) |
Contents
Contributors, xxvii
Editor's Preface, xxxv
Section I: An overview of mesenchymal stem cells
and mesenchymal stromal cells
1 The mesenchymal stem cell, the mesenchymal
stromal cell, and the mesenchymal stromal cell exosome, 3
2 The nomenclature of mesenchymal stem cells
and mesenchymal stromal cells, 8
Section II: The isolation and ex vivo
expansion of mesenchymal stromal cells
3 The isolation and expansion of mesenchymal
stromal cells from bone marrow, 13
4 The biology and clinical applications of
mesenchymal stromal cells derived from human gestational tissues, 24
5 Human placenta-derived mesenchymal
stem/stromal cells: fetal and maternal origins and critical parameters for ex
vivo expansion, 32
Section III: The cellular and molecular
biology of mesenchymal stromal cells
6 Epigenetic regulation of mesenchymal
stem/stromal cell growth and multipotentiality, 41
7 Biological changes in human mesenchymal
stromal cells during monolayer culture, 58
8 The effect of three-dimensional aggregates
on the biology of mesenchymal stromal cells, 75
9 Cell-cell signaling pathways that regulate
mesenchymal stromal cell differentiation, 91
10 Regulation of mitochondrial transport in
mesenchymal stromal cells, 104
11 The regulation of adipogenesis from
adipose-derived stem/stromal cells, 114
12 Modulation of osteogenic differentiation
in mesenchymal stromal cells, 131
13 The role of glycogen synthase kinase-3
inhibitors on bone remodeling, 148
14 Early molecular events during in vitro
chondrogenesis, 167
15 The role of the extracellular matrix in
the differentiation of mesenchymal stromal cells, 191
16 Effects of hypoxic culture on bone marrow
multipotent mesenchymal stromal cells: from bench to bedside, 196
17 The role of cyclic tensile strain on
osteogenesis and angiogenesis in human mesenchymal stem/stromal cells, 208
18 The evolving concept of mesenchymal
stromal cells in regenerative medicine: from cell differentiation to secretome,
222
19 The secretome of mesenchymal stem/stromal
cells undergoing chondrogenic differentiation and those undergoing osteogenic
or adipogenic differentiation, 236
20 Mesenchymal stromal cell extracellular
vesicles/exosomes, 250
21 Role of tunneling nanotube crosstalk with
distressed cardiomyocytes in controlling the heart repair potential of
mesenchymal stromal cells, 264
22 The preferential homing of mesenchymal
stromal cells to sites of inflammation, 286
23 The role of chemokines in mesenchymal
stromal cell homing to sites of inflammation, including infarcted myocardium,
314
24 Live cell imaging and single cell
tracking of mesenchymal stromal cells in vitro, 323
25 The role of mesenchymal stem/stromal
cells in angiogenesis, 347
26 The relationship between mesenchymal
stromal cells and endothelial cells, 366
27 The radioresistance of mesenchymal
stromal cells and their potential role in the management of radiation injury,
391
28 The implications of multipotent
mesenchymal stromal cells in tumor biology and therapy, 415
29 Mesenchymal stem/stromal cell therapy:
mechanism of action and host response, 426
30 The differences between mesenchymal
stromal cells and fibroblasts, 441
31 Derivation of mesenchymal stem/stromal
cells from induced pluripotent stem cells, 456
32 The role of mesenchymal stem cells in
hematopoiesis, 467
33 The modulatory effects of mesenchymal
stromal cells on the innate immune system, 481
34 The modulatory effects of mesenchymal
stromal cells on the adaptive immune system, 490
35 The role of mesenchymal stromal cells in
the repair of acute organ injury, 496
36 The use of mesenchymal stromal cells in
the treatment of diseases of the cornea, 524
37 The role of paracrine factors secreted by
mesenchymal stromal cells in acute tissue injury, 544
38 Treatment of lung disease by mesenchymal
stromal cell extracellular vesicles, 553
39 Evaluating mesenchymal stem/stromal cells
for treatment of asthma and allergic rhinitis, 573
40 Stem cell therapies for Huntington's
disease, 581
Section IV: The role of bioengineering in
the therapeutic applications of Mesenchymal stromal cells
41 Endometrial mesenchymal stromal cell and
tissue engineering for pelvic organ prolapse repair, 601
42 Closed automated large-scale bioreactors
for manufacturing mesenchymal stromal cells for clinical use, 616
Section V: GMP manufacturing of mesenchymal
stromal cells for clinical use
43 Current good manufacturing practice for
the isolation and ex vivo expansion of mesenchymal stromal cells derived from
term human placenta for use in clinical trials, 621
44 A comparison of high-tier regulatory
documents pertaining to biologic drugs including mesenchymal stromal cells in
Australia, Europe, and the USA using a manual documentary analysis, 628
Section VI: The therapeutic application of mesenchymal
stromal cells
45 The use of mesenchymal stromal cells in
acute and chronic heart disease, 647
46 The role of mesenchymal stem/stromal
cells in the management of critical limb ischemia, 661
47 The role of mesenchymal stromal cells in
the management of musculoskeletal disorders, 677
48 The potential role of bone marrow
mesenchymal stromal cells in the treatment of ischemic stroke, 690
49 The role of mesenchymal stromal cells in
spinal cord injury, 714
50 The role of mesenchymal stromal cells in
the treatment of ulcerative colitis and Crohn's disease, 730
51 Mesenchymal stromal cells targeting
kidney disease: benefits of a combined therapeutic approach, 754
52 The biology and potential clinical
applications of mesenchymal stromal cells in diseases of the lung, 770
53 The role of mesenchymal stromal cells in
diseases of the lung, 787
54 Mesenchymal stromal cells for the
treatment of autoimmune diseases, 794
55 The role of mesenchymal stromal cells in
bacterial infection, 814
56 The use of mesenchymal stromal cells in
solid organ transplantation, 825
57 The role of mesenchymal stromal cells in
allogeneic hematopoietic stem cell transplantation, 836
58 The role of mesenchymal stromal cells in
the management of skin wounds, 841
59 The role of mesenchymal stromal cells in
skin wound healing, 845
Section VII: Mesenchymal stromal cells as delivery
vehicles for therapeutic agents
60 The role of mesenchymal stromal cells in
human brain tumors, 859
61 Mesenchymal stromal cells as gene
delivery vehicles to treat nonmalignant diseases, 873
62 Gene therapy for cancer using mesenchymal
stromal cells, 892
Section VIII: The present and the future
63 Breaking news, 901
64 Reconciling the stem cell and paracrine
paradigms of mesenchymal stem cell function, 912
Glossary, 927
Index, 949
