Stem cells between regeneration and tumorigenesis / Cristiana Tanase & Monica Neagu. -- Sharjah : Bentham Science Publishers, 2016. – (58.155/S824b)

Contents

FOREWORD  i

PREFACE  iii

LIST OF CONTRIBUTORS  vi

CHAPTER 1  STEM CELLS IN HEMATOPOIETIC PROCESSES AND THERAPY TOOLS  3

HEMATOPOIETIC STEM CELLS (HSCS)  4

BIOLOGICAL REGULATION OF HEMATOPOIETIC STEM CELLS  8

THERAPEUTIC APPLICATION OF HSCS  14

CONFLICT OF INTEREST  25

ACKNOWLEDGEMENTS  25

REFERENCES  25

CHAPTER 2  EPITHELIAL ORAL STEM CELLS  37

INTRODUCTION  37

CONCLUSIVE REMARKS  50

CONFLICT OF INTEREST  51

ACKNOWLEDGEMENTS  51

REFERENCES  51

CHAPTER 3  SKIN STEM CELLS IN CUTANEOUS WOUND HEALING AND TUMORIGENESIS  63

INTRODUCTION  63

SKIN STEM CELLS IN REGENERATION AND WOUND HEALING  71

LINKING REGENERATION TO TUMORIGENESIS  75

CANCER STEM CELL - MAJOR PLAYER IN SKIN TUMORIGENESIS  78

CONCLUSIVE REMARKS  87

CONFLICT OF INTEREST  87

ACKNOWLEDGEMENTS  88

REFERENCES  88

CHAPTER 4 STEM CELLS IN NEURODEGENERATION  106

INTRODUCTION  106

NEURAL STEM CELL NICHE ORGANIZATION IN ADULT MAMMALIAN BRAIN  107

MAINTENANCE OF NEURAL STEM CELL NICHE IN THE OLD BRAIN  109

NEUROREGENERATION RESERVE IN NEURODEGENERATIVE DISEASES  112

USE  OF  STEM  CELLS  AS  THERAPEUTIC  APPROACHES  IN NEURODEGENERATIVE DISORDERS  114

CONCLUSION  120

CONFLICT OF INTEREST  121

ACKNOWLEDGEMENTS  121

REFERENCES  121

CHAPTER 5  CANCER STEM CELLS IN BRAIN TUMORIGENESIS  133

INTRODUCTION  134

CANCER STEM CELLS AND THE TUMOR MALIGNANCY GRADE  134

CANCER STEM/TUMOR-INITIATING CELLS  137

MARKERS RELATED WITH GCSCs  139

CANCER STEM-CELL NICHE  141

SIGNALING PATHWAY DEREGULATIONS  143

FUTURE THERAPIES IN BRAIN TUMORS TARGETING CANCER STEM CELLS  152

CONCLUSION  157

CONFLICT OF INTEREST  158

ACKNOWLEDGEMENTS  158

REFERENCES  159

CHAPTER 6  ADULT PITUITARY STEM CELLS  172

INTRODUCTION  172

THE FOLLICULO-STELLATE CELLS  173

STEM CELLS OF ADULT PITUITARY GLAND  175

CONCLUSION  181

CONFLICT OF INTEREST  181

ACKNOWLEDGEMENTS  181

REFERENCES  181

CHAPTER 7  CANCER STEM CELLS IN PANCREATIC AND HEPATOCELLULAR CARCINOMA: SIMILARITIES AND DIFFERENCES  187

INTRODUCTION  187

PERSPECTIVES

CONFLICT OF INTEREST  197

ACKNOWLEDGEMENTS  197

REFERENCES

CHAPTER 8  IMMUNOGENICITY OF STEM CELL IN TUMORIGENESIS VERSUS REGENERATION

INTRODUCTION

IMMUNOGENICITY OF STEM CELLS - CHARACTERIZING MHC EXPRESSION  207

INNATE IMMUNE RESPONSES TOWARD PLURIPOTENT STEM CELLS  213

ADAPTIVE IMMUNE RESPONSES TOWARD PLURIPOTENT STEM CELLS  214

UNFOLDING IMMUNE-RELATED MECHANISMS FOR DRIVING PLURIPOTENT STEM CELLS TOWARDS TUMORIGENESIS OR REGENERATION  216

CANCER STEM CELLS - AN IMMUNOLOGICAL DISTINCT POPULATION OF STEM CELLS?

CLINICAL TRIALS- HOW FAR FROM THE BEDSIDE APPLICATION OF STEM CELLS?  220

CONCLUSIVE REMARKS  221

CONFLICT OF INTEREST  223

ACKNOWLEDGEMENTS

REFERENCES

CHAPTER 9  CURRENT PROTEOMIC STUDIES FOR NEW CONCEPT IN STEM CELL BIOLOGY 235

INTRODUCTION

PROTEOMICS VERSUS TRANSCRIPTOMICS IN STEM CELLS    238

EMBRYONIC STEM CELLS PROTEOMICS  241

ADULT STEM CELLS PROTEOMICS  242

SIGNALING PATHWAYS IN STEM CELLS  247

INTERACTOMICS IN STEM CELLS  251

CANCER STEM CELLS AND PROTEOMICS  255

STEM CELLS SECRETOME  262

BIOINFORMATICS - OMICS DATA ANALYSIS  264

CONCLUSION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS  267

REFERENCES

CHAPTER 10  NANO  AND  MICROTECHNOLOGY  FOR  MONITORING  STEM CELL DIFFERENTIATION  281

INTRODUCTION  282

THE NEED TO MONITOR SC DIFFERENTIATION IN THE CONTEXT OF THEIR RESEARCH AND THERAPEUTIC APPLICATIONS  283

TECHNOLOGIES FOR MONITORING SC DIFFERENTIATION  288

CONCLUSION  312

CONFLICT OF INTEREST  312

ACKNOWLEDGEMENTS  312

REFERENCES  312

SUBJECT INDEX  321