 |
Cell biology : translational impact in cancer biology and bioinformatics / Maika G. Mitchell. -- Amsterdam : Academic Press is an imprint of Elsevier, c2016. – (58.15 /M682) |
Contents
1. Clinical Utility/Relevance of Cell Biology
Techniques
What Is Clinical
Utility/Relevance
Signal
Transduction
Cell
Division
Cell
Differentiation
Apoptosis
Cell and
Tissue Morphogenesis
Cell
Migration
What Are
the Informatics Challenges in Quantitative Cell Biology Imaging?
Why Are
Open Source Approaches Essential?
Open
Source Tools for Data Acquisition, Visualization, Analysis, and Dissemination
Supporting
Open Source Software
Partnering
Commercial and Open Source Efforts
Summary
Introduction
to Controlled Drug Delivery Systems
Advantages
of Controlled Delivery Systems
History
of Controlled Drug Delivery
Sustained
Release Drug Delivery Systems
Advantages
of Sustained Release Systems
Sustained
Release Mechanisms
Liposomes
in Drug Delivery
What Are
Liposomes?
Liposomes
in Drug Targeting
Types of
Liposome Targeting
Nanoparticles
in Drug Delivery
Advantages
and Disadvantages of Nanoparticles
Drug
Loading Procedures
Applications
of Nanoparticles
Nanospheres
What Is
Molecular Nanotechnology?
Background
and Definitions
Evolution
of the Biopolymer
Synthetic
Absorbable Polyesters
Poly(Ortho
Esters)
Poly(Ortho
Ester) III
Poly(Ortho
Ester) IV
Polyanhydrides
as Carriers of Drugs
Bioabsorbable
Poly(Ester-Amides)
Amino
Acid-Derived Polymers
Applications
Comments
Polyphosphazenes
as New Biomaterials
Bacterial
Polyesters: Structural Variability in Microbial Synthesis
Biosynthetic
Polysaccharides
Chitosan
Pullulan
Elsinan
Chemical
Modifications of Proteins and Polysaccharides and Its Effect on
Enzyme-Catalyzed Degradation
Red
Blood Cells as Drug Carriers
Introduction
Drug
Loading
Red
Blood Cells as Drug Carriers against Retroviruses
Polymerization
and Characterization of Biopolymers
Polymerization
Characterization
Mathematical
Models for Controlled Release Mechanism
Mixing/Diffusion
Process: Flory's Model
Rubber
Elasticity: Simple Mechanical Model
Dynamic
Model of Electrolyte Gel
Chemical
Capacitance Model
Electric
Potential Capacitance Model
Kinetic
Model
Dextran
Sulfate: Pharmaceutical Uses
References
Target
Drug Delivery and the Blood-Brain Barrier
Introduction
History
Structure
and Function
Transport
Glucose
Transport
Amino
Acid Transport
Peptide
Transport
Disorders
of the Blood-Brain Barrier
Getting
Past the Barrier
Routes
and Methods of Administration
Nonpharmaceutical
Methods
Tailored
and Carrier Drugs
Mechanical
Disruption
Artificial
Cells
Introduction
Methods
of Preparation
Microencapsulation
of Bioactive Sorbents
Microencapsulation
of Cells or Microorganisms
Microencapsulation
of Genetically Engineered Cells
Microencapsulation
of Enzymes and Multienzyme Systems
Red
Blood Cell Substitutes
Biodegradable
Artificial Cells
General
Discussions
General
Discussion
Bibliography
Appendices
Appendix
A: Glossary of Technical Terms
Appendix
B: Chronological History of Nanotechnology
Chronology
of Significant Events in Nanotechnology Research
Appendix
C: List of Symbols
History
and Facts on the Evolution of Nanotechnology
MITRE
Corporation's List of Nanotechnology Research Sites
DoD Task
Force Forecasts for 1998-2020
References
Bibliography
2. Applications
of 3D Printing in Cell Biology
Computer
Aided Design Model Used for 3D Printing
Model of
a Turbine Showing the Benefits of 3D Printing in Industry
3D
Modeling
Printing
Finishing
Current
Uses
3D
Printing, a Key Technology for Making Biobots
Synthetic
Organs
Projected
Uses in NASA Space Program
Science
Objectives for Everyone
Space
Applications
Earth
Applications
Operationa
Operationa
Requirements
Protocols
How the
3D Printer Will Be Useful in the Future
Fabrication
of Tissue-Engineered Constructs
Bioprinting
Bioprinting
Technologies
Alginate
and Chitosan as Biomaterial
Fabrication
Technologies for Vasculature Network
Fabrication
of Vascular Conduits
Materials
and Methods
Fabrication
Process
Coaxial
Nozzle
Results
Discussion
and Conclusion
Dispensing
through the Coaxial Nozzle
Cell Viability
Distribution over the Cross Section
Discussion
and Conclusion
Results
Evaluation
of Media Perfusion Capabilities
Materials
and Methods
Media
Perfusion System
Embedding
a Vasculature System into Bulk Hydroge
Perfusion
and Diffusional Characterization
Quantitative
Measurement of Small Molecular Diffusivity
Reference
3. Transforming
Bench Work Cell Biology with Cancer Informatics: From Silos to Systems
Cancer
Researchers and Data Mining
Definition
of Data Mining
Data
Mining General Models
General Application
of Data Mining
Application
of Data Mining in Cancer Studies
Guiding
Principles for an Integrated Data Warehouse
Introduction
Data
Warehouse Architecture
Building
Cancer Data Warehouse
References
4. Overview
of the Cancer Informatics Landscape
Telemedicine
E-health
Health
Systems
Hospital
Information Systems
Health
Information Systems
Cloud-Based
Informatics Platforms
Application
of Cloud Computing in Health Care
Excel
Macros for Data Analysis
References
5. Current
Trends for Global Coalition of all STEM Stakeholders via Cancer Informatics
Challenges
to Integrating Genomics
Health
Information Technology Infrastructure
Putting
Thoughts into Action
EHRs as
a Research Tool
The
100,000 Genomes Project
Advancing
Research and Patient Care
Other Genetic
Research Resources
Opportunities
Translation
of Genomics for Patient Care and Research
Engaging
Patients
The
Platform for Engaging Everyone Responsibly
Patient
Trust, Consent, and Opting In
Platform-Supported,
Complete Learning Cycles
Simultaneous
Learning Cycles
Health-Care
Disparities
Improving
Health with a Knowledge-Based System
Innovation
within Health Systems
Managing
Priorities in a Health System
Promoting
Health Services Research
Using
Genomic Data in the Clinic
Leveraging
EHRs for Genomics
Creating
a Supportive Infrastructure
Clinical
Decision Support
Managing
Big Data
Insurance
and
Data
Sharing
Standards
and
Use
Cases
Regulatory
Issues
Scale
Potential
Next Steps and Considerations
Possible
Next Steps
EHR
Interoperability
Clinical
Decision Support
Understanding
Consumer Value and Preferences
References
6. Conclusion
and Discussion
Future
Trends in Cancer Cell Biology and Informatics
Introduction
Objective
Scope
Non-Scope
Responsibility
Specimens
Specimen
Type
Validation
Specimen Collection, Storage, and Preparation
Instrumentation
Reagents
Validation
Summary
Veridex
CellTracks AutoPrep Procedure
Specimen
Preparation
Setup of
CellTracks AutoPrep System Run
Loading
AutoPrep
Index
Unloading
Specimens from AutoPrep
Control
Specimen Analysis and QC
CellTracks
Analyzer II Image Acqulslt,on
Identification
of Control CTCs
Control
Spec
Clinical
Spec
men QC
men
Analysis
Generate
Specimen Reports
Acceptance/Rejection
Criteria for Identification of CTCs
Rubicon
PicoPlex WGA of CTCs
Initial
Preparation of CTCs
WGA
Protocol
Analyzing
Amplification Efficiency Results
Purifying
and Quantifying PicoPlex Products
The DNA
Clean & Concentrator~-5 Protocol
DNA
Purification Procedure
LightMix~
Kit HER2/neu Oncogene Detection Protoco
Interpretation
of HER2/neu qPCR Results
CTC
Recovery (Total for Each 10 mL Tube of Human Whole Blood)
Sensitivity
and Reproducibility of Veridex CellSearch System
Sensitivity
and Reproducibility of HER2/neu Oncogene Amplification and Detection
Method
Comparison of CTC Enumeration
Necessary
Preparations before Starting the Enrichment Procedure
Preparation
of Washing Buffer
Enrichment
Procedure
Deviations
Conclusions
References
Appendix
Friedman
Test
Descriptive
Statistics
Correlation
Coefficient
Passing
and Bablok Regression
Repeated
Measures ANOVA
Repeated
Measures ANOVA on Log-Transformed Data
