Advances in genetics. Volume 93 / edited by Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin. -- Waltham, Massachusetts : Academic Press, 2016. – (58.14/A244/v.93)

Contents

Contributors

1. The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer--Understanding the Basis of a Rapidly Evolving Disease

1. Introduction

2. The Genome of Human Papillomavirus-Associated Head and Neck Cancer

3. The Epigenome of Human Papillomavirus-Associated Head and Neck Cancer

4. The Transcriptome of Human Papillomavirus-Associated Head and Neck Cancer

5. Biomarker Development for Human Papillomavirus-Associated Oropharyngea Cancer

6. Linking the Cancer-Associated Changes--A Model of Human Papillomavirus-Associated Head and Neck Cancer Development

7. Future Directions

Acknowledgments

References

2. Translating Lung Function Genome-Wide Association Study (GWAS) Findings: New Insights for Lung Biology                 57

1. Genetics of Lung Function and COPD

2. Standing on the Shoulders of Giants: A Brief Historical Overview of Molecular Genetics and Functional Studies in Pulmonary Physiology

3. The Landscape of GWAS for Lung Function and COPD

4. In silico Approaches in Translational Studies

5. In vivo Methods to Translate GWAS Findings

6. In vitro Approaches Using Human Cells to Translate GWAS Findings

7. Inferred Biology of Selected and Most Reproducible Lung Function Genes

8. Summary and Future Perspectives

Competing Interests

Acknowledgments

References

3. Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases                147

1. Introduction

2. Overview of Omics Technologies and Association Studies

3. Genetic and Environmental Determinants of Epigenomic, Transcriptomic, Metabolomic, and Proteomic Markers

4. Analytical Approaches and Methods for Multiomic Association Studies

5. Discussion

Acknowledgments

References

4. Yeast and Fungal Prions: Amyloid-Handling Systems, Amyloid Structure, and Prion Biology                                 191

1. Introduction

2. Discovery of Yeast Prions

3. Prion Domains

4. The Roll Call of Prions

5. Prion Variants/Strains and Transmission Barriers

6. Structure of Infectious Amyloid of Yeast and Fungal Prions

7. Yeast Priori Amyloid Structure Explains Inheritance of Conformation

8. Prion Biology

9. Cellular Systems Affecting Yeast Prions

10. Perspectives and Controversies

Acknowledgments

References