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The membranes of cells / Philip L. Yeagle. -- 3rd ed. -- Amsterdam : Elsevier/Academic Press, c2016. – (58.1551/Y37/3rd ed.) |
Contents
Preface
1. Introduction
1.1 Prokaryote Cell Membranes
1.2 Eukaryote Cell Membranes
1.3 Plasma Membranes
1.4 Intracellular Membranes
1.5 Viral Membranes
1.6 Membrane Motifs
1.7 The Hydrophobic Effect
1.8 Structure of Water
1.9 Nonpolar Molecules and Water
1.10 Highlights
References
2. The Lipids of
Biological Membranes
2.1 Phospholipids
2.2 Sphingolipids
2.3 Glycolipids
2.4 Sterols
2.5 Two-Headed Lipids
2.6 Lipopolysaccharide
2.7 Lipid Identification
2.8 Highlights
References
3. Biogenesis of
Membrane Lipids
3.1 Desaturation of Fatty Acids
3.2 Biosynthesis of Phospholipids
3.3 Biosynthesis ofgphingolipids
3.4 Cholesterol Biosynthesis
3.5 Assembly of Newly Synthesized Lipids into
Membranes
3.6 Highlights
References
4. Detergents
4.1 Nonionic Detergents
4.2 Ionic Detergents
4.3 Detergent Properties
4.4 Detergents and Membrane Rafts
4.5 Highlights
References
5. Membrane Models
5.1 The Evidence for the Lipid Bilayer
5.2 The Singer Nicholson Model for Membranes
5.3 Current Model for Biological Membranes
5.4 Highlights
References
6. Laboratory
Membrane Systems
6.1 Structure of Laboratory Membrane Systems
6.2 Properties Derived from Laboratory Membrane
.Systems
6.3 Hydration
6.4 Ion Binding
6.5 Highlights
References
7. Structures of
Lipid Assemblies
7.1 Lamellar
(Bilayer) Structure
7.2 Interdigitated
Bilayers
7.3 Micellar Phase
7.4 Hexagonal I
Phase (HI)
7.5 Hexagonal II
Phase (H.)
7.6 Cubic Phase
7.7 Subphase for
Phospholipid Bilayers
7.8 Solution Phase
7.9 Lipid Phase
Transitions
7.10 Phase
Transitions in Cell Membranes
7.11 Lamellar to
H,j Phase Transition
7.12 Lipid
Microdomains in Membranes
7.13 Lipid
Conformation in Membranes
7.14 Water in the
Lipid Bilayer
7.15 Highlights
References
8. Lipid Dynamics in Membranes
8.1 Introduction
155
8.2 ESR 156
8.3 2H NMR
156
8.4 Motional Order 158
8.5 Motional Rates 167
8.6 Integrated View of Motional Order and
Dynamics
8.7 Membrane Fluidity
8.8 Free Volume Within a Membrane Bilayer
8.9 Lateral Diffusion of Membrane Components
8.10 Lateral Phase
Separation
8.11 Transmembrane
Movement of Lipids
8.12 Movement of
Phospholipids Between Membranes
8.13 Transmembrane
Lipid Asymmetry
8.14 Highlights
References
9. Cholesterol and
Related Sterols: Roles in Membrane Structure and Function
9.1 Structure and Properties of the Cholesterol
Molecule
9.2 Cholesterol Location in Cells
9.3 Cholesterol Modulates Membrane Physical
Properties
9.4 Role of Sterols in SteroI-Requiring Cells
9.5 Essential Role of Cholesterol in Mammalian
and Other SteroI-Requiring Cells
9.6 Hypothesis for a Specific Sterol Requirement
9.7 Highlights
References
10. Membrane
Proteins
10.1
Classification of Membrane Proteins
10.2 Peripheral
Membrane Proteins
10.3 Integral
Membrane Proteins
10.4 Primary
Structure of Membrane Proteins
10.5 Secondary
Structure of Integral Membrane Proteins
10.6 Tertiary
Structure of Membrane Proteins
10.7 Quaternary
Structure of Membrane Proteins
10.8
Three-Dimensional Structure of Integral Membrane Proteins-- Experimental
Approaches
10.9 Principles of
Membrane Protein Structure
10.10 Domain
Structure of Membrane Proteins
10.11 Membrane
Protein Stability
10.12 Dynamics of
Membrane Proteins in Membranes
10.13 Membrane
Protein Asymmetry in Membranes
10.14
Posttranslational Modification of Membrane Proteins
10.15 Highlights
References
11. Membrane
Biogenesis
1.1 Assembly of
Newly Synthesized Lipids into Membranes
269
1.2 Transport of
Lipids to Target Membranes
274
1.3 Membrane
Protein Biosynthesis
277
1.4 Biosynthesis
and Insertion of Integral Membrane Proteins into Endoplasmic Reticulum
11.5
Posttranslational Modifications of Membrane Proteins
11.6 Degradation
of Membrane Proteins
11.7 Highlights
References
12. Lipid-Protein
Interactions in Membranes
12.1 Influence of Membrane Proteins on Bulk
Membrane Lipid Properties in a Bilayer
12.2 Specific
Lipid Influence on Membrane Protein Function
12.3 Tight
Noncovalent Binding of Lipids to Membrane Proteins
12.4 Pleckstrin
Homology Domains
12.5 Phospholipase
Binding to Phospholipid Substrate
12.6 Boundary
Lipids in Membranes Containing Transmembrane Proteins
12.7 Dynamics of
Lipids Interacting with Membrane Proteins
12.8 Membrane
Proteins and Rafts
12.9 Proteins That
Bend Bilayers
12.10 Lipids
Covalently Bonded to Proteins
12.11
Reconstitution
12.12 Highlights
References
13. Membrane
Transport
13.1 Passive Diffusion
13.2 Facilitated
Diffusion
13.3 Active
Transport
13.3.3 Sarco(endo)plasmic Reticulum Calcium Pump
13.3.4 ATP Synthase
13.3.5 Phosphotransferase System of Bacteria
13.4 Highlights
References
14. Membrane
Fusion
14.1 Fundamentals of the Membrane Fusion Process
14.2 Measurement
of Membrane Fusion
14.3 Fusion of
Phospholipid Vesicles
14.4 Virus Fusion
14.5 Sendai Virus
14.6 Influenza
Virus
14.7 Intracellular
Membrane Fusion
14.8 Highlights
References
15. Membrane
Receptors
15.1 LDL Receptor 401
15.2
Receptor-Mediated Endocytosis 403
15.3 Transferrin
Receptor
405
15.4 Receptor
Tyrosine Kinases--lnsulin Receptor
406
15.5 Receptor Tyrosine Kinases--Epidermal Growth
Factor Receptor 408
15.6
NicotinicAcetylcholine Receptor 409
15.7 Integrins,
Adhesion Receptors
411
15.8 Guanylyl
Cyclase Receptors
412
15.9 G-Protein
Coupled Receptors
413
15.10
Highlights 421
References
422
Index
