Advances in genetics. Volume 91 / edited by Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin. -- Amsterdam : Academic Press, 2015. – (58.14/A244/v.91)

Contents

Contributors

1. Functional Significance of TDP-43 Mutations in Disease

1. Introduction

2. TARDBP Mutation Spectrum

3. Clinical Significance of TDP-43 Mutations

4. Functional Consequences of TDP-43 Mutations

5. RNA-Specific Therapies for TDP-43 Mutations

6. Conclusions and Future Perspectives

Acknowledgments

References

2. Distinct RNAi Pathways in the Regulation of Physiology and Development in the Fungus Mucor circinelloides

1. Introduction

2. Discovery of Gene Silencing in M. circinelloides

3. Elements of RNAi Machinery in M. circinelloides

4. Physiological and Developmental Responses Regulated by the RNA) Machinery 73

5. Different Classes of Endogenous Small RNAs (esRNAs) Regulate Gene Expression

6. A Noncanonical RNAi Pathway to Regulate mRNA Accumulation in M. circinelloides

7. A Hypothesis for the Origin of the RNAi Mechanism

8. Conclusions

Acknowledgments

References

3. Getting Down to Specifics: Profiling Gene Expression and Protein-DNA Interactions in a Cell Type-Specific Manner

1. Introduction

2. Expressing Transgenes for the Purpose of Cell Type-Specific Profiling

3. Profiling Transcriptiona Activity and Protein-DNA Interactions by Cell/Nuclei Isolation

4. Profiling Transcriptiona Activity and Protein-DNA Interactions without Cell/Nuclei Isolation

5. Discussion

Acknowledgments

References

Index