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Advances in genetics. Volume 92 / edited by Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin. -- Waltham, Massachusetts : Academic Press, 2015. – (58.14/A244/v.92)

Contents

Contributors

1. Understanding and Editing the Zebrafish Genome

1. Introduction

2. Genomics Resources

3. Transgenesis Vectors

4. Mutagenesis Resources

5. Conclusions and Future Perspectives

Acknowledgments

References

2. Life without Food and the Implications for Neurodegeneration     53

1. Introduction

2. Metabolic Restructuring during Diapause

3. Saving Energy by Means of Na+/K+ ATPase Downregulation

4. Neuroprotection in Dormant States

Acknowledgments

References

3. Decoding Advances in Psychiatric Genetics: A Focus on Neural Circuits in Rodent Models

1. Introduction

2. Brief Overview of Genetics of SCZ

3. Putting Psychiatric Genetics to Work

4. Prioritizing Phenotyping Strategies for Animal Models of Psychiatric Disorders

5. Conclusion

Acknowledgments

References

4. Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other Fungi

1. Let's Talk a Few Minutes About Clocks

2. From Phenotypes to Genes: The Early Days

3. The Neurospora Circadian System at the Molecular Level

4. Circadian Clocks and Temporal Coordination of Biological Processes in Other Fungi

5. Concluding Remarks

Acknowledgments

References

Index

:.5'>5. TM4SFS-Dependent Drug Resistance

6. TM4SF5-Dependent Self-Renewal Capacity

7. Conclusion

Acknowledgments

References

5. Emerging Roles of JmjC Domain-Containing Proteins

1. Introduction

2. Histone Modification and Methylation

3. Histone Demethylation and Demethylases

4. Plant JmjC Histone Demethylation

5. Conclusions

References

6. New Insight into the Role of Reactive Oxygen Species (ROS) in Cellular SignaI-Transduction Processes

1. Introduction

2. Background

3. Targets of Redox Regulation

4. Others

5. Pathophysiological Significance

6. Treatment Strategies Involving ROS Modulation

7. Measurement of ROS

8. Conclusions and Future Perspectives

References

7. Regeneration, Stem Cells, and Aging in the Tunicate Ciono: Insights from the Oral Siphon

1. Introduction

2. Background

3. OS Regeneration

4. Adult Stem Cells

5. Stem and Progenitor Cell Mobilization and Deployment

6. Aging and OS Regeneration

7. Concluding Remarks and Perspectives

Acknowledgments

References

Index