International review of cell and molecular biology. Volume 314 / edited by Kwang W. Jeon. -- Amsterdam : Academic Press, c2015. – (58.15/I61/v.314)

Contents

    CONTENTS
    
    Contributors
    1. Epidermal Growth Factor Signaling in Transformed Cells
    1. Introduction
    2. Hallmarks of Transformation
    3. The ErbB/HER Receptor Family in Normal and Transformed Cells
    4. EGFR Signaling in Normal and Transformed Cells
    5. Cross Talk between EGFR Signaling and Other Major Signaling Pathways in Transformed Cells
    6. Therapy
    7. Concluding Remarks
    Acknowledgments
    References
    2. New Insights into Antimetastatic and Antiangiogenic Effects of Cannabinoids
    1. Introduction
    2. Cannabinoids as Systemic Anticancer Drugs
    3. Cannabinoids and Tumor Angiogenesis
    4. Effects of Cannabinoids on Tumor Cell Metastasis
    5. Conclusion
    References
    3. Insight into the Role of Wnt5a-lnduced Signaling in Normal and Cancer Cells
    1. Introduction
    2. WntSa-Ror2 Axis in Developmental Morphogenesis
    3. Roles of WntSa-Ror2 Axis in Normal Cell Functions
    4. WntSa-Ror2 and Ror1 Axes in Cancer Cells
    5. Concluding Remarks
    Acknowledgments
    References
    4. New Insight into Cancer Aneuploidy in Zebrafish
    1. Introduction
    2. The Cause of Aneuploidy
    3. Biological Effects of Aneuploidy
    4. Zebrafish as a Cancer Model for Human Cancers
    5. Cancer Driver Genes on Aneuploid Chromosomes
    6. Future Directions
    Acknowledgments
    References
    5. The Amazing Ubiquitin-Proteasome System: Structural Components and Implication in Aging
    1. Introduction
    2. Aging
    3. The Ubiquitin System
    4. The Proteasome
    5. Regulation of the Ub System during Cellular Senescence and In vivo Aging
    6. Implication of ERAD and OMMAD in Cellular Senescence and In vivo Aging
    7. Alterations of the Proteasome Functionality during Cellular Senescence and In vivo Aging
    8. Modulation of the UPS as an Antiaging Approach
    9. Conclusive Remarks and Perspectives
    Acknowledgments
    Conflict of Interest
    References
    6. Biogenesis and Function of the NGF/TrkA Signaling Endosome 239
    1. Introduction
    2. NGF
    3. TrkA
    4. The Signaling Endosome
    5. Concluding Remarks
    Acknowledgments
    References
    7. Multiple Myeloma as a Model for the Role of Bone Marrow Niches in the Control of Angiogenesis
    1. Introduction
    2. EPCs and MSCs
    3. Vascular Niche
    4. Osteoblastic Niche
    5. MM Niche and Angiogenesis
    6. Targeting Angiogenesis in the MM Niche
    7. Concluding Remarks
    Acknowledgments
    References
    Index