Epigenomics, from chromatin biology to therapeutics / edited by Krishnarao Appasani ; forword by Azim Surani. -- Cambridge ; New York : Cambridge University Press, c2012. – (58.1484 /E64) |
Contents
CONTENTS
List of contributors
Foreword
Preface
Part I. Basics of Chromatin Biology and Biochemistry:
1. Introduction to epigenomics
2. Epigenetics and its historical perspectives
3. Functional networks of human epigenetic factors
4. Nucleosome positioning in promoters: significance and open questions
5. Chemical reporters of protein methylation and acetylation
6. Long non-coding RNA in epigenetic gene silencing
Part II. Epigenomic Imprinting and Stem Cells:
7. Active DNA demethylation - the enigma starts in the zygote
8. Histone modifications of lineage specific genes in human embryonic stem cells during in vitro differentiation
9. Epigenetic stability of human pluripotent stem cells
10. Impact of CpG methylation in addressing adipose derived stem cell differentiation towards the cardiac phenotype
11. Regulation of stem cell epigenome by REST
12. MicroRNAs in embryonic stem cells
13. Regulation of timing of replication
Part III. Epigenomic Assays and Sequencing Technology:
14. Detection of CpG methylation patterns by affinity capture methods
15. Genome-wide ChIP-DSL profiling of promoter methylation patterns associated with cancer and stem cell differentiation
16. Quantitative, high-resolution CpG methylation assays on the pyrosequencing platform
17. DNA methylation profiling using Illumina BeadArray platform
18. Advances in capillary electrophoresis-based methods for DNA methylation analysis
19. Genome-wide methylome analysis based on new HT sequencing technology
20. 3-D quantitative DNA methylation imaging for chromatin texture analysis in pharmacoepigenomics and toxicoepigenomics
Part IV. Epigenomics in Disease Biology:
21. Cancer classification by genome-wide and quantitative DNA methylation analyses
22. Promoter CpG island methylation in colorectal cancer: biology and clinical applications
23. The epigenetic profile of bladder cancer
24. Genome-scale DNA methylation analyses of cancer in children
25. The epigenetics of facioscapulohumeral muscular dystrophy
26. Modulating histone acetylation with inhibitors and activators
Part V. Epigenomics in Neurodegenerative Diseases:
27. Study design considerations in epigenetic studies of neuropsychiatric disease
28. Epigenetic regulation in human neurodevelopmental disorders including autism, Rett syndrome and epilepsy
29. The neurobiology of chromatin-associated mechanisms in the context of psychosis and mood spectrum disorders
30. Genome-wide DNA methylation analysis in patients with familial ATR-X mental retardation syndrome
31. Kinases and phosphatases in the epigenetic regulation of cognitive functions
Part VI. Epigenetic Variation, Polymorphism and Epidemiological Perspectives:
32. Epigenetic effects of childhood abuse on the human brain
33. X-linked expressed SNPs and dosage compensation
34. Epigenomic diversity of colorectal cancer
35. Epigenetic epidemiology: transgenerational responses to the environment
Index