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MicroRNAs in development and cancer / editor, Frank J. Slack. — London : Hackensack, NJ : Imperial College Press ; World Scientific [distributor], c2011. – (64.8/M626) |
Contents
Contents
1 Introduction to Gene Regulation by Small RNAs
1.1 Introduction
1.2 Gene Regulation by MicroRNAs
1.3 Gene Regulation by piRNAs
1.4 Summary and Perspectives
Acknowledgments
References
2 The Emerging Non-Coding RNA World
2.1 Introduction to Non-Coding RNAs
2.2 Classifications of Long ncRNAs Based on Genomic Organisation
2.3 Emerging Functional Themes of Long ncRNAs
2.4 Non-Coding RNAs in Human Disease
2.5 Conclusion
References
3 MicroRNAs in C. elegans Development
3.1 Introduction
3.2 MicroRNA Biogenesis
3.3 The Mechanism of Action of C. elegans miRNAs
3.4 MicroRNA Targets and Their Prediction
3.5 'Small Temporal RNAs' and the Heterochronic Pathway
3.6 The lin-4 miRNA Family
3.7 The let-7 miRNA Family
3.8 Regulation of Neuronal Differentiation by mir-273 and lsy-6
3.9 Mir-l， a Highly Conserved， Muscle-Specific miRNA
3.10 MiR-61 as a Regulator of Vulval Differentiation
3.11 Few miRNAs Appear to be Individually Important for C. elegans Development
3.12 Elucidating the Function of Uncharacterised miRNAs
3.13 MiRNA Regulatory Networks
3.14 Conclusions and Outlook
Acknowledgments
References
4 MicroRNAs in Mammalian Development
4.1 Introduction
4.2 Processing of miRNAs
4.3 Deletion of Dicer and Drosha in ES Cells
4.4 Conditional Deletion of Drosha， DGCR8 and Dicer
4.5 Deletion of Argonaute in Mice
4.6 Biological Functions of Individual miRNAs
4.7 MicroRNAs in Hematopoiesis and the Immune System
4.8 MiR-181a
4.9 MiR-155
4.10 MiR-17-92 and Paralogues
4.11 MiR-150
4.12 MiR-223
4.13 MiRNAs in Heart Development and Function
4.14 The miR-1N133 Family of miRNA Clusters
4.15 MyomiRs
4.16 MiR-203 and Skin Development
4.17 Conclusion
Acknowledgments
References
5 MicroRNAs in Hematopoietic Development
5.1 Introduction
5.2 MiRNA Biogenesis and Post-Transcriptional Regulation
5.3 MiRNA Target Recognition and 3' UTR Regulation
5.4 Interplay Between miRNAs and Transcription Factors in Hematopoiesis
5.5 MiRNA Biogenesis' Role in Hematopoietic Development and Inflammation
5.6 Control of Cell Survival and Cell Proliferation
5.7 Control of Cell Differentiation
5.8 MiRNAs and Adaptive Immune Responses
5.9 MiRNAs and Innate Immune Responses
5.10 Perspective
Acknowledgments
References
6 MicroRNAs Function as Tumor Suppressor Genes and Oncogenes
6.1 Introduction: MicroRNAs are Closely Linked with Cancer
6.2 MiRNAs Control a Variety of Developmental Processes Related to Cancer Progression Pathways
6.3 MicroRNA Biogenesis and Cancer
6.4 MiRNA Dysregulation and Disease
6.5 A Role for MicroRNAs in Metastasis
6.6 Conclusions and Future Outlook
References
7 Simultaneous Detection of Primary， Precursor and Mature MicroRNAs by qPCR
7.1 Introduction
7.2 Description of the Technology
7.3 Examples That Use the Technology
7.4 Conclusions and Prospects
Acknowledgments
References
8 Single Nucleotide Polymorphisms in MicroRNAs and MicroRNA Binding Sites with Roles in Cancer
8.1 MiRNAs as Oncogenes and Tumour Suppressors
8.2 MiRNA Profiling
8.3 Dual Roles for MiRNAs as Oncogenes and Tumour Suppressors
8.4 Single Nucleotide Polymorphisms (SNPs) Associated with MiRNA Genes
8.5 SNPs in MiRNA Binding Sites
8.6 MiRNA-Associated SNPs Associated with Cancer
8.7 Conclusions
References
9 MicroRNAs as Potential Diagnostics and Therapeutics
9.1 MicroRNAs in Cancer Diagnostics
9.2 MicroRNAs in Cancer Therapeutics
Conclusions
Acknowledgments
References
10 MicroRNA Target Prediction
10.1 Introduction
10.2 Definitions and Background
10.3 Methods
10.4 Estimating Performance
10.5 Availability of Tools and Predictions
10.6 Conclusion
References
11 Non-Coding RNAs in Cancer -- The Other Part of the Story
11.1 Introduction
11.2 UCGs: Location and Expression Profiles Prove a Cancer Link
11.3 UCGs as Oncogenes or Tumour Suppressor Genes
11.4 Regulation of UCG Expression
11.5 Sequence Variations in UCRs and Cancer Risk
11.6 PiRNAs and Cancer
11.7 Conclusion
Acknowledgments
References
Index
