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Tumor microenvironment / edited by Dietmar W. Siemann. — Oxford : Wiley-Blackwell, c2011. – (64.83/T925) |
Contents
Contents
Preface
List of Contributors
1 The Microenvironment in Cancer
1.1 Introduction
1.2 A highly selective process is required to obtain the cancer phenotype
1.3 The cancer phenotype
1.4 The extracellular matrix
1.5 Motility， invasion， and metastatic ability
1.6 Impact of the tumor microenvironment on the control of cancer
1.7 Targeting the tumor microenvironment
1.8 Summary
References
2 Establishing the Tumor Microenvironment
2.1 Introduction
2.2 From cancerous cells to a tumor
2.3 A tumor is more than cancer cells and fibroblasts
2.4 Communication between the tumor cells and stroma
2.5 Hypoxia and angiogenesis
2.6 Conclusion
Acknowledgements
References
Further reading
3 Contributions of the Extracellular Matrix to Tumorigenesis 35
3.1 The extracellular matrix
3.2 Manipulation of the ECM during tumor development
3.3 Matricellular proteins and their complex effects on tumor development
3.4 Conclusion
References
4 Matrix Metalloproteinases and Their Inhibitors - Friend or Foe 53
4.1 Introduction
4.2 Matrix metalloproteinases
4.3 Tissue inhibitors of matrix metalloproteinases
4.4 Concluding comments
References
5 Role of Tumor-Associated Macrophages (TAM) in Cancer Related Inflammation
5.1 Introduction
5.2 Functional plasticity of macrophages
5.3 Macrophages as key orchestrators of cancer-related inflammation
5.4 Recruitment and differentiation of TAM
5.5 Protumoral functions of TAM
5.6 Molecular determinants of TAM functions
5.7 Therapeutic targeting of TAM
5.8 Conclusions
References
6 Bone Marrow Stroma and the Leukemic Microenvironment 99
6.1 Introduction
6.2 Components and function of the normal bone
6.3 Leukemia and its microenvironment
6.4 Summary
References
7 Microenvironment factors influencing skeletal metastases
7.1 Introduction
7.2 The bone microenvironment as a target for cancer cell dissemination
7.3 Roles of the bone microenvironment in promoting the arrest of circulating cancer cells at the skeleton
7.4 Concluding remarks
References
8 Premetastatic Niches
8.1 Introduction
8.2 'Seeds' influencing the 'Soil'
8.3 Cellular components of premetastatic niches
8.4 ECM components of premetastatic niches
8.5 Premetastatic niche formation precedes metastatic growth
8.6 Therapeutic targeting of the premetastatic niche
8.7 Evidence for premetastatic niches in the clinic
8.8 Concluding remarks
References
9 Hypoxia， Anerobic Metabolism， and Interstitial Hypertension 183
9.1 Introduction
9.2 Pathophysiology of the tumor microenvironment
9.3 Evaluating the tumor microenvironment
9.4 Biologic and therapeutic implications
9.5 Clinical implications
9.6 Summary
References
10 Hypoxia and the DNA Damage Response
10.1 Introduction
10.2 The DNA damage response
10.3 Hypoxia regulation of DNA repair
10.4 Context synthetic lethality: exploiting hypoxic deregulation of DNA repair
10.5 Conclusions
References
11 Non-Invasive Imaging of the Tumor Microenvironment
11.1 Introduction
11.2 Imaging tumor vasculature， perfusion， and angiogenesis
11.3 Imaging tumor hypoxia: chronic and acute
11.4 Imaging tumor oxygen consumption
11.5 EPR oximetry
11.6 Imaging tumor interstitial fluid pressure (IFP)
11.7 Imaging tumor pH
11.8 Imaging tumor redox status
11.9 Imaging tumor response
11.10 Optimizing therapeutic intervention using molecular imaging
11.11 Conclusions
References
Further reading
12 Hypoxia-Inducible Factor 1 (HIF1) Mediated Adaptive Responses in the Solid Tumor
12.1 Introduction
12.2 Molecular consequences of tumor hypoxia
12.3 Hypoxia inducible factor 1
12.4 HIF-1 subunits and domain structure
12.5 Regulation of HIF-1α protein stability and activity by post-translational modifications
12.6 HIF isoforms
12.7 Oxygen-independent HIF signaling
12.8 HIF target genes
12.9 Hypoxia and oxygen delivery
12.10 Hypoxia and glucose metabolism
12.11 Hypoxia and acidosis
12.12 Hypoxia and metastasis
12.13 Therapeutic implications
References
13 Regulation of the Unfolded Protein Response in Cancer 291
13.1 Introduction
13.2 The UPR signaling cascade
13.3 Hypoxia activates UPR
13.4 UPR and expression of UPR-targeted genes in cancer
13.5 Concluding remarks
References
14 Influence of Hypoxia on Metastatic Spread
14.1 Introduction
14.2 The metastatic process
14.3 The tumor microenvironment and metastasis
14.4 Summary
References
15 Drug Penetration and Therapeutic Resistance
15.1 Introduction
15.2 Tumor microenvironment
15.3 Drug penetration
15.4 In vitro tumor models
15.5 Conclusions
References
16 Impact on Radiotherapy
16.1 Introduction
16.2 The tumour vasculature and microenvironment
16.3 Influence of tumor hypoxia on radiation therapy
16.4 Reducing hypoxia by increasing oxygen delivery
16.5 Radiosensitizing hypoxic cells
16.6 Killing the resistant cell population
16.7 Vascular targeting approaches
16.8 Conclusions and future perspectives
References
17 HIF-1 Inhibitors for Cancer Therapy
17.1 Introduction
17.2 Small molecule inhibitors of HIF-1
17.3 Exploiting HIF-1 inhibitors in combination strategies
17.4 Conclusions
Acknowledgements
References
18 Vascular-Targeted Molecular Therapy
18.1 Introduction
18.2 Approaches to targeting tumor vasculature in vivo
18.3 Alternative targeting strategies
18.4 Concluding remarks
Acknowledgements
References
Index
