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新书资源(2011年4月)

Cell signalling / John T. Hancock. — 3rd ed. — Oxford : Oxford University Press, c2010. – (58.1574/H234/3rd ed.)

Contents

    C0NTENTS
    
    LIST OF FIGURES
    LIST OF TABLES
    LIST OF ABBREVIATIONS
    Part 1: An overview of signalling
    1 Aspects of cellular signalling
    1.1 Introduction
    1.2 The main principles of cell signalling
    1.3 What makes a good signal?
    1.4 Different ways in which cells signal to each other
    1.5 Amplification and physical architectures
    1.6 Coordination of signalling
    1.7 Domains and modules
    1.8 Oncogenes
    Summary
    Further reading
    2 Pathways are the key to signalling
    2.1 Introduction
    2.2 Simplified examples of signalling pathways
    Summary
    Further reading
    3 A look at some of the history and techniques of cell signalling
    3.1 A brief history
    3.2 A brief look at some techniques
    Summary
    Further reading
    Part 2: Components that comprise signalling pathways
    4 Extracellular signals: hormones, cytokines and growth factors
    4.1 Introduction
    4.2 Hormones
    4.3 Plant hormones
    4.4 Cytokines
    4.5 Growth factors
    4.6 Neurotransmitters
    4.7 ATP as an extracellular signa
    4.8 Pheromones
    Summary
    Further reading
    5 Detection of extracellular signals: the role of receptors
    5.1 Introduction
    5.2 Types of receptors
    5.3 Ligand binding to their receptors
    5.4 Receptor sensitivity and receptor density
    Summary
    Further reading
    6 Protein phosphorylation, kinases and phosphatases
    6.1 Introduction
    6.2 Serine/threonine kinases
    6.3 Tyrosine kinases
    6.4 Mitogen-activated protein kinases
    6.5 Histidine phosphorylation
    6.6 Phosphatases
    6.7 Other covalent modifications
    6.8 Ubiquitin-proteasome system
    Summary
    Further reading
    7 Cyclic nucleotides, cyclases and G proteins
    7.1 Introduction
    7.2 cAMP
    7.3 Adenylyl cyclase
    7.4 Adenylyl cyclase control and the robe of G proteins
    7.5 Other robes of the heterotrimeric G proteins
    7.6 Guanylyl cyclase
    7.7 Phosphodiesterases
    7.8 Compartmentalization of nucleotide signalling
    7.9 The GTPase superfamily: functions of monomeric G proteins
    Summary
    Further reading
    8 Inositol phosphate metabolism and roles of membrane lipids
    8.1 Introduction
    8.2 Events at the membrane
    8.3 The breakdown of the inositol phosphate lipids
    8.4 Inositol 1,4,5-trisphosphate and its fate
    8.5 The role of diacylglycerol
    8.6 Inositol phosphate metabolism at the nucleus
    8.7 Other lipids involved in signalling
    8.8 Related lipid derived signalling molecules
    Summary
    Further reading
    Intracellular calcium: its control and role as an intracellular signa
    9.1 Introduction
    9.2 Calmodulin
    9.3 The plasma membrane and its role in calcium concentration maintenance
    9.4 Intracellular stores
    9.5 Gradients, waves and oscillations
    9.6 Sphingosine-l-phosphate
    9.7 Cyclic ADP-ribose
    9.8 Nicotinate adenine-dinucleotide phosphate
    9.9 Fluorescence detection and confocal microscopy
    Summary
    Further reading
    10 Reactive oxygen species, reactive nitrogen species and redox signalling
    10.1 Introduction
    10.2 Nitric oxide
    10.3 Reactive oxygen species: superoxide and hydrogen peroxide
    10.4 Redox signalling and molecular mechanisms of hydrogen peroxide signalling
    10.5 Measuring ROS and RNS
    10.6 Carbon monoxide and other compounds
    Summary
    Further reading
    Part 3: Selected examples of signalling pathways and events 265
    11 Insulin and the signal transduction cascades it invokes
    11.1 The insulin signalling system
    Summary
    Further reading
    12 Perception of the environment
    12.1 introduction
    12.2 Photodetection in the eye
    12.3 Other environment perception systems
    Summary
    Further reading
    13 Signalling in development and for the regulation of gene expression
    13.1 Introduction
    13.2 Transcription factors
    13.3 Transforming growth factor 13
    13.4 Notch receptor signalling
    13.5 Hedgehog signalling
    13.6 Wnt signalling
    13.7 Toll-like receptor signalling
    Summary
    Further reading
    14 Life, death and apoptosis
    14.1 Introduction
    14.2 An overview of apoptosis
    14.3 Caspases
    14.4 The intrinsic pathway
    14.5 The extrinsic pathway
    Summary
    Further reading
    Part 4: Final thoughts
    15 Cell signalling: importance, complexity and the future
    15.1 Introduction
    15.2 Specificity, subtlety and crosstalk
    15.3 Longer term effects
    15.4 The future
    Further reading
    INDEX