Cell signalling / John T. Hancock. — 3rd ed. — Oxford : Oxford University Press, c2010. – (58.1574/H234/3rd ed.) |
Contents
C0NTENTS
LIST OF FIGURES
LIST OF TABLES
LIST OF ABBREVIATIONS
Part 1: An overview of signalling
1 Aspects of cellular signalling
1.1 Introduction
1.2 The main principles of cell signalling
1.3 What makes a good signal?
1.4 Different ways in which cells signal to each other
1.5 Amplification and physical architectures
1.6 Coordination of signalling
1.7 Domains and modules
1.8 Oncogenes
Summary
Further reading
2 Pathways are the key to signalling
2.1 Introduction
2.2 Simplified examples of signalling pathways
Summary
Further reading
3 A look at some of the history and techniques of cell signalling
3.1 A brief history
3.2 A brief look at some techniques
Summary
Further reading
Part 2: Components that comprise signalling pathways
4 Extracellular signals: hormones, cytokines and growth factors
4.1 Introduction
4.2 Hormones
4.3 Plant hormones
4.4 Cytokines
4.5 Growth factors
4.6 Neurotransmitters
4.7 ATP as an extracellular signa
4.8 Pheromones
Summary
Further reading
5 Detection of extracellular signals: the role of receptors
5.1 Introduction
5.2 Types of receptors
5.3 Ligand binding to their receptors
5.4 Receptor sensitivity and receptor density
Summary
Further reading
6 Protein phosphorylation, kinases and phosphatases
6.1 Introduction
6.2 Serine/threonine kinases
6.3 Tyrosine kinases
6.4 Mitogen-activated protein kinases
6.5 Histidine phosphorylation
6.6 Phosphatases
6.7 Other covalent modifications
6.8 Ubiquitin-proteasome system
Summary
Further reading
7 Cyclic nucleotides, cyclases and G proteins
7.1 Introduction
7.2 cAMP
7.3 Adenylyl cyclase
7.4 Adenylyl cyclase control and the robe of G proteins
7.5 Other robes of the heterotrimeric G proteins
7.6 Guanylyl cyclase
7.7 Phosphodiesterases
7.8 Compartmentalization of nucleotide signalling
7.9 The GTPase superfamily: functions of monomeric G proteins
Summary
Further reading
8 Inositol phosphate metabolism and roles of membrane lipids
8.1 Introduction
8.2 Events at the membrane
8.3 The breakdown of the inositol phosphate lipids
8.4 Inositol 1,4,5-trisphosphate and its fate
8.5 The role of diacylglycerol
8.6 Inositol phosphate metabolism at the nucleus
8.7 Other lipids involved in signalling
8.8 Related lipid derived signalling molecules
Summary
Further reading
Intracellular calcium: its control and role as an intracellular signa
9.1 Introduction
9.2 Calmodulin
9.3 The plasma membrane and its role in calcium concentration maintenance
9.4 Intracellular stores
9.5 Gradients, waves and oscillations
9.6 Sphingosine-l-phosphate
9.7 Cyclic ADP-ribose
9.8 Nicotinate adenine-dinucleotide phosphate
9.9 Fluorescence detection and confocal microscopy
Summary
Further reading
10 Reactive oxygen species, reactive nitrogen species and redox signalling
10.1 Introduction
10.2 Nitric oxide
10.3 Reactive oxygen species: superoxide and hydrogen peroxide
10.4 Redox signalling and molecular mechanisms of hydrogen peroxide signalling
10.5 Measuring ROS and RNS
10.6 Carbon monoxide and other compounds
Summary
Further reading
Part 3: Selected examples of signalling pathways and events 265
11 Insulin and the signal transduction cascades it invokes
11.1 The insulin signalling system
Summary
Further reading
12 Perception of the environment
12.1 introduction
12.2 Photodetection in the eye
12.3 Other environment perception systems
Summary
Further reading
13 Signalling in development and for the regulation of gene expression
13.1 Introduction
13.2 Transcription factors
13.3 Transforming growth factor 13
13.4 Notch receptor signalling
13.5 Hedgehog signalling
13.6 Wnt signalling
13.7 Toll-like receptor signalling
Summary
Further reading
14 Life, death and apoptosis
14.1 Introduction
14.2 An overview of apoptosis
14.3 Caspases
14.4 The intrinsic pathway
14.5 The extrinsic pathway
Summary
Further reading
Part 4: Final thoughts
15 Cell signalling: importance, complexity and the future
15.1 Introduction
15.2 Specificity, subtlety and crosstalk
15.3 Longer term effects
15.4 The future
Further reading
INDEX