Clinical and translational science : principles of human research / edited by David Robertson, Gordon H. Williams. — Amsterdam ; London : Academic, c2009. – (63/C641)

Contents

    Contents
    
    Foreword by Garret A. FitzGerald
    Acknowledgments
    Introduction to Clinical Research
    Part I Fundamental Principles
    1 Patient-Oriented Research: Clinical Pathophysiology and Clinical Therapeutics
    2 Clinical Trials
    Part II Approaches
    3 Experimental Design
    4 Introduction to Biostatistics Ideas
    5 Measurement of Biological Materials
    6 Imaging Tools in Human Research 87
    7 Imaging Tools in Cardiovascular Research
    8 Nanotechnology in Clinical and Translational Research 123
    9 The Use of Questionnaires and Surveys 137
    10 Information Technology 155
    Part III Infrastructure
    11 Clinical and Translational Science Infrastructure 171
    12 Industry-Sponsored Clinical Research in Academia 183
    Part IV Education， Training and Career Choices
    13 Training Basic， Clinical and Translational Investigators 191
    14 A Stepwise Approach to a Career in Translational Research 201
    15 Physician Careers in Industry 207
    Part V Funding
    16 Governmental Support of Research 219
    17 Support of Health Research by Private Philanthropy
    18 Pharmaceutical and Biotechnology Sector Support of Research 255
    Part VI Human Genetics
    19 Introduction to Human Genetics 265
    20 Epidemiologic and Population Genetic Studies 289
    21 Pharmacogenetics of Drug Metabolism
    Part VII Human Pharmacology
    22 Introduction to Clinical Pharmacology
    23 Toxicology and Genetics of Adverse Drug Events 339
    24 Good Clinical Practice and Good Laboratory Practice 345
    25 Modern Drug Discovery and Development 361
    Part VIII Societal Context of Human Research
    26 Translating Science to the Bedside: The Innovation Pipeline 383
    27 Regulatory Environment 401
    28 Ethical Issues in Translational Research and Clinical Investigation
    29 Clinical Research in the Public Eye 429
    Part IX Research in Special Populations
    30 Acute Illnesses， Critical Care， Emergency and Surgical Patients 443
    31 Psychiatric Disorders 461
    32 Geriatrics 477
    33 Pediatrics 497
    Part X Population-Based Research
    34 Pharmacoeconomics: The Economic Evaluation of New Medical Technology
    35 Introduction to Epidemiology 527
    36 Health Services Research: Translating Discovery and Research into Practice and Policy 543
    Part Xl Prospectus
    37 The Future of Clinical Research
    Index