Biology of stem cells and the molecular basis of the stem state / by Dov Zipori. — Dordrecht ; London : Springer, 2009. – (58.22/Z79)

Contents

    Contents
    
    Prologue
    Chapter Summaries
    1 Historical Roots
    1.1 The Stem Cell Notion: Is There a Stem Cell for Each and Every Hemopoietic Cell Type?
    1.2 The Emergence of Bone Marrow Transplantation
    1.3 The Origin of Contemporary Notions on Stem Cells
    1.4 Conclusions， Questions， and Enigmas
    References
    2 Multipotency and Tissue-Specific Stem Cells
    2.l Tissue-Specific Stem Cells from Organs Capable of Extensive Regeneration
    2.2 Tissue-Specific Stem Cells from Organs Undergoing Extensive Repopulation and Repair
    2.3 Tissue-Specific Stem Cells in Tissues and Organs Exhibiting Moderate Repopulation and Repair Capabilities
    2.4 Tissue-Specific Stem Cells in Tissues and Organs Exhibiting Poor Regeneration and Repair Capabilities
    2.5 Conclusions， Questions， and Enigmas
    References
    3 Stem Cells with No Tissue Specificity
    3.1 Mesenchymal Cells: A Body-Wide Distributed Population that Includes Multipotent Cells
    3.2 Adult Pluripotent Stern Cells
    3.3 The Case of ESCs
    3.4 Conclusions， Questions， and Enigmas
    4 Stem Cell Niches
    4.1 Universality of the Stem Cell Niche Concept: From Plants to Mammalians
    4.2 The Cellular and Molecular Structure of Stem Cell Niches
    4.3 Studies on Mammalian Stem Cell Self-Renewal: Relevance to the Niche
    4.4 The Molecular Basis of Asymmetrical Divisions
    4.5 Homeless Orphans: Stem Cells with Unknown Niches
    4.6 Conclusions， Questions， and Enigmas 134
    References 140
    5 A Critical Analysis of Properties Commonly Ascribed to Stem Cells 151
    5.1 Stem Cell Definitions Vary 151
    5.2 Specific Markers 152
    5.3 In Vitro Versus In Vivo
    5.4 The Issue of Rareness
    5.5 The Undifferentiated State: Is Any Cell that Precedes the Other Within the Differentiation Cascade， a Stem Cell?
    5.6 Quiescence
    5.7 Self-Renewal
    5.8 Indefinite Renewal
    5.9 Extensive Proliferation
    5.10 Niche Dependence
    5.11 Symmetric Versus Asymmetric Divisions
    5.12 Robust Regeneration and Reconstitution of Tissues
    5.13 Migration and Homing
    5.14 Differentiation Capacity
    5.15 Multipotency and Pluripotency
    5.16 Conclusions
    References
    6 The Stem State: Sternness as a State in the Cell's Life Cycle
    6.1 The Stem Cell Versus the Stem State
    6.2 The Molecular Basis of Stemness: A Specific Gene Expression Pattern Versus Epigenetic Modulations
    6.3 Dedifferentiation
    6.4 Transdifferentiation
    6.5 Reprogramming by Enforcing Dedifferentiation and Transdifferentiation Artificially
    6.6 The Stem State
    6.7 Conclusions， Questions， and Enigmas 203
    References
    7 The Stem State in Cancer
    7.1 Tumorigenesis and Tumor Growth
    7.2 The Tumor-Initiating Cell
    7.3 Tumor Stem Cells
    7.4 Inconsistencies and Contradictions Within the Tumor Stem Cell Theory
    7.5 TICs are Biologically Distinct from Stem Cells: The TIC Does Not Possess Any of the Major Traits of Normal Stem Cells
    7.6 Tumors are Stem Cell-Deficient
    7.7 Conclusions and Enigmas
    References
    8 MSC Therapy in Animal Models and in Regenerative Medicine for Human Diseases 245
    8.1 Progenitor Cell Therapy: General Considerations 245
    8.2 BMT: Transplantation of Unmanipulated Cells， Shortly After Their Isolation
    8.3 Transplantation of Ex Vivo Propagated MSCs as a Therapy Modality 250
    8.4 Transplantation of Ex Vivo Propagated， Genetically Manipulated Cells
    8.5 Ex Vivo and In Vivo Engineering of Complete Tissues and Organs
    8.6 Future Prospects: The Awakening of Resident Stem Cells
    References
    Epilogue
    Index