Cell death / editors, Gerry Melino, David Vaux. — Oxford : Wiley-Blackwell, 2010. – (58.1574/C393q)

Contents

    Contents
    
    Contributors
    Preface
    The Siren's Song: This Death That Makes Life Live
    The Origin and Evolution of Programmed Cell Death
    Cell Death in C. elegans
    Caspases and Cell Death
    The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis
    Caspases， Substrates and Sequential Activation
    Dismantling the Apoptotic Cell
    The BCL-2 Family Proteins Key Regulators and Effectors of Apoptosis
    BH3-only Proteins
    Mitochondrial Outer Membrane Permeabilization 90
    Mitochondria Fusion and Fission 97
    Death Receptors
    Death Receptors at the Molecular Level Therapeutic Implications
    Death Receptor-induced Necroptosis 127
    Inhibitor of Apoptosis (IAP) and BIR-containing Proteins
    Structures， Domains and Functions in Cell Death (DD， DED， CARD， PYD)
    Structure and Function of IAP and Bcl-2 Proteins 156
    Engulfment of Apoptotic Cells and its Physiological Roles
    Autophagy 175
    Autophagy in Nonmammalian Systems
    Apoptosis: Regulatory Genes and Disease 197
    Caspases in Inflammation and Immunity
    Immunity， Granzymes and Cell Killing 223
    P53 and Cell Death 230
    Cornification of the Skin: A Non-apoptotic Cell Death Mechanism
    Apoptosis: Inherited Disorders
    From Reactive Oxygen and Nitrogen Species to Therapy
    Microbial Inhibitors of Apoptosis
    Drug Discovery in Apoptosis