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Essential physiological biochemistry : an organ-based approach / Stephen Reed. — Chichester : Wiley-Blackwell, c2009. – (58.173/R326) |
Contents
Contents
Preface
1 Introduction to metabolism
Overview of the chapter
1.1 Introduction
1.2 Metabolic pathways
1.3 Organization of pathways
1.4 Enzymes and enzyme-mediated reactions
1.5 Bioenergetics: an introduction to biological thermodynamics
1.6 Enzyme-mediated control of metabolic pathways
1.7 Strategy for learning the details of a pathway: 'active learning' is essential
Chapter summary
Problems and challenges
2 Dynamic and quantitative aspects of metabolism: bioenergetics and enzyme kinetics
Overview of the chapter
2.1 Introduction
2.2 Bioenergetics: the application of thermodynamic principles to biological systems
2.3 Enzyme kinetics
2.4 Energy generating metabolic processes
Chapter summary
Problems and challenges
3 Principles of metabolic control: enzymes， substrates， inhibitors and genes
Overview of the chapter
3.1 Introduction
3.2 General principles
3.3 Glycolysis and the Krebs TCA cycle as models of control of metabolic pathways
Chapter summary
Problems and challenges
4 Biochemistry of intercellular communication; metabolic integration and coordination
Overview of the chapter
Key pathways
4.1 Introduction
4.2 Physiological aspects
4.3 Signalling molecules
4.4 Synthesis of hormones
4.5 Hormone and neurotransmitter storage， release and transport
4.6 Hormone and neurotransmitter inactivation
4.7 Target tissue response to signals
4.8 Diabetes mellitus
Chapter summary
Case notes
5 Biochemistry of the blood and the vascular system
Overview of the chapter
Key pathways
5.1 Introduction
5.2 The blood vascular system
5.3 Circulating blood cells
5.4 Coagulation and complement: two of the body's defence mechanisms
5.5 Blood as a transport medium
Chapter summary
Case notes
6 Biochemistry of the liver
Overview of the chapter
Key pathways
6.1 Introduction
6.2 Physiology of the liver
6.3 Synthetic functions
6.4 Detoxification and waste disposal
6.5 Maintenance of blood glucose concentration
Chapter summary
Case notes
7 Biochemistry of muscle
Overview of the chapter
Key pathways
7.1 Introduction
7.2 Physiology of muscles
7.3 Fuel metabolism within muscles
7.4 Maintenance of ATP availability in active muscle
7.5 Fatty acid as a fuel in muscle
7.6 Proteins and amino acids as fuels
7.7 Fuel utilization by muscle: adaptation to exercise and training
Chapter summary
Case notes
8 Biochemistry of the kidneys
Overview of the chapter
Key pathways
8.1 Introduction
8.2 Renal physiology
8.3 Metabolic pathways in the kidneys
Chapter summary
Case notes
9 Biochemistry of connective tissue: bone and adipose
Overview of the chapter
Key pathways
9.1 Introduction
9.2 Histology of connective tissue
9.3 The ECM of connective tissue
9.4 Bone
9.5 Cartilage
9.6 Adipose tissue
Chapter summary
Case notes
Appendix 1 Answers to problems
Appendix 2 Table of important metabolic pathways
Index
