Vitamin K in health and disease / John W. Suttie. — Boca Raton : CRC Press, c2009. – (61.1152/S967)

Contents

    Contents
    
    Preface ix
    Author xi
    Chapter 1 Historical Background 1
    References 9
    Chapter 2 Active Forms， Antagonists， Physical Properties， and Synthesis of Vitamin K 13
    2.1 Nomenclature and Structures of K Vitamers 13
    2.2 Active Forms of Vitamin K 14
    2.3 Antagonists of Vitamin K Action 20
    2.4 Use of Vitamin K to Supplement Diets and Rations 27
    2.5 Synthesis of Vitamin K 28
    2.6 Physical and Chemical Properties of Vitamin K 31
    References 33
    Chapter 3 Dietary Intake of Vitamin K and the Vitamin K Content of Foods and Plasma 39
    3.1 Methodology 39
    3.2 Vitamin K in Foods 41
    3.3 Vitamin K Content of Human Plasma 50
    3.4 Current Status of Research Efforts 54
    References 55
    Chapter 4 Vitamin K-Dependent Carboxylase and Vitamin K Epoxide Reductase 63
    4.1 Vitamin K-Dependent Carboxylase 63
    4.2 The Vitamin K-Epoxide Reductase 78
    4.3 Current Status of Research Efforts 82
    References 83
    Chapter 5 Vitamin K-Dependent Proteins 93
    5.1 How Extensive Are Vitamin K-Dependent Proteins? 93
    5.2 Vitamin K-Dependent Clotting Factors 93
    5.3 Vitamin K-Dependent Proteins Found in Skeletal Tissue 107
    5.4 Vitamin K-Dependent Proteins and Peptides in Venoms 111
    5.5 Other Vitamin K-Dependent Proteins 114
    5.6 Current Status of Research Efforts 117
    References 118
    Chapter 6 Absorption， Storage， and Metabolism of Vitamin K 133
    6.1 Absorption， Bioavailability， and Plasma Transport 133
    6.2 Utilization of Menaquinones from the Gut 139
    6.3 Vitamin K in Various Organs and Tissues 141
    6.4 Tissue Metabolism of Vitamin K 145
    6.5 Current Status of Research Efforts 152
    References 153
    Chapter 7 Public Health Concerns Related to Vitamin K Status 161
    7.1 Vitamin K Deficiencies 161
    7.2 Control of Anticoagulant Therapy 165
    7.3 Vitamin K and Bone Health 169
    7.4 Vitamin K Status and Calcification-Related Diseases 174
    7.5 Current Status of Research Efforts 177
    References 179
    Chapter 8 Vitamin K Requirements， Toxicity， and Other Metabolic Interactions 195
    8.1 Dietary Reference Intakes for Vitamin K 195
    8.2 Vitamin K Requirement of Domestic and Companion Animals 200
    8.3 Dietary and Physiological Factors Influencing Vitamin K Status 204
    8.4 Hazards of the Ingestion of Large Amounts of Vitamin K 206
    8.5 Additional Reports of Biological Effects of Vitamin K 207
    References 209
    Index 217