Red cell development / edited by James J. Bieker. — London : Academic, c2008. – (58.12/C976/v.82)

Contents

    CONTENTS
    
    Contributors
    Preface
    1. Ontogeny of Erythropoiesis in the Mammalian Embryo
     1. Introduction
     2. Primitive Erythropoiesis
     3. "Definitive" Erythropoiesis in the Fetus
     4. Developmental Origins of Erythropoiesis
     5. Conclusions
     Acknowledgments
     References
    2. The Erythroblastic Island
     1. Introduction
     2. Composition and Sites of Formation of Erythroblastic Islands
     3. Cell-Cell Adhesive Interactions Within Erythroblastic Islands
     4. Erythroblastic Island Functions
     5. Conclusion
     Acknowledgments
     References
    3. Epigenetic Control of Complex Loci During Erythropoiesis
     1. Introduction
     2. Utility of Analyzing Erythropoiesis to Dissect Epigenetic Mechanisms
     3. Epigenetic Control of the/~-like Globin Genes During Erythropoiesis
     4. Epigenetic Control of the Gata2 Locus During Erythropoiesis
     5. Principles of Epigenetic Control Emerging from Studies of Erythropoiesis
     Acknowledgments
     References
    4. The Role of the Epigenetic Signal， DNA Methylation， in Gene Regulation During Erythroid Development 85
     1. Introduction
     2. DNA Methylation in Erythroid Cell Differentiation
     3. The fl-Globin Locus: A Model for the Role of DNA Methylation in Developmental Gene Regulation
     4. DNA Methylation of the Human ~-Globin Locus
     5. DNA Methylation of Other Erythroid-Specific Genes
     6. Conclusions and Future Directions
     Acknowledgments
     References
    5. Three-Dimensional Organization of Gene Expression in Erythroid Cells
     1. Introduction: Three-Dimensional studies in a historical context
     2. Long-Range Gene Activation and gene competition: DNA-Folding Matters?
     3. Novel Biochemical Approaches to Study DNA Topology: Insight into the Spatial Organization of the fl-Globin Locus
     4. The Functional Significance of Long-Range Interactions Between Regulatory Sequences
     5. Long-Range Contacts in Other 6ene Loci
     6. Gene Positioning in the Nucleus: Spatial Coordination of Functionally Related Genes?
     7. Future Directions for Studies on Nuclear Architecture: 4C Technology
    References
    6. Iron Homeostasis and Erythropoiesis
     1. Introduction
     2. Iron Metabolism and Homeostasis
     3. Hepcidin
     4. Hepcidin and Erythropoeisis
     5. Conclusions
     References
    7. Effects of Nitric Oxide on Red Blood Cell Development and Phenotype
     1. Nitric Oxide
     2. NO Influence on Cell Differentiation
     3. NO Interaction with RBCs
     4. Effects of NO on Hemoglobin Expression
     5. Role of NO During Malaria Pathogenesis
     6. Effects of Fetal Hemoglobin Inducers on NO-cGMP Pathway
     7. Summary: NO and Erythropoiesis
     References
    8. Diamond Blackfan Anemia: A Disorder of Red Blood Cell Development
     1. Introduction
     2. Pathophysiology and Genetics: DBA， a Disorder of Ribosome Biosynthesis
     3. Other Diseases Linked to Defects in Ribosome Synthesis
     4. Ribosome Dysfunction and Red Blood Cell Development
     5. DBA Is a Cancer Predisposition Syndrome
     6. Treatment and Outcomes
     7. Summary
     References
     Index
     Contents of Previous Volumes