Eukaryotic transcription factors / by David S. Latchman. — 5th ed. — Amsterdam : Elsevier / Academic Press, c2008. – (58.1483/L351/5th ed.)

Contents

    CONTENTS
    
    List of tables
    About the author
    Preface
    Preface to the fourth edition
    Preface to the third edition
    Preface to the second edition
    Preface to the first edition
    Acknowledgements
    1. DNA SEQUENCES， TRANSCRIPTION FACTORS AND CHROMATIN STRUCTURE
     1.1. The importance of transcription
     1.2. Chromatin structure and its remodelling
     1.3. DNA sequence elements
     1.4. Conclusions
     References
    2. METHODS FOR STUDYING TRANSCRIPTION FACTORS
     2.1. Introduction
     2.2. Methods for studying DNA-protein interactions
     2.3. Methods for purifying and/or cloning transcription factors
     2.4. Use of cloned genes
     2.5. Conclusions
     References
    3. RNA POLYMERASES AND THE BASAL TRANSCRIPTIONAL COMPLEX
     3.1. RNA polymerases
     3.2. The stable transcriptional complex
     3.3. RNA polymerase I
     3.4. RNA polymerase III
     3.5. RNA polymerase II
     3.6. TBP: the universal transcription factor?
     3.7. Transcriptional elongation
     3.8. Conclusions
     References
    4. FAMILIES OF DNA BINDING TRANSCRIPTION FACTORS
     4.1. Introduction
     4.2. The homeodomain
     4.3. The two cysteine two histidine Zinc finger
     4.4. The multi-cysteine Zinc finger
     4.5. The basic DNA binding domain
     4.6. Other DNA binding motifs
     4.7. Conclusions
     References
    5 ACTIVATION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS
     5.1. Activation domains
     5.2. Nature of activation domains
     5.3. Interaction of activation domains with the basal transcriptional complex
     5.4. Interaction of activation domains with other regulatory proteins
     5.5. Effect of transcriptional activators on chromatin structure
     5.6. Stimulation of transcriptional elongation
     5.7. Conclusions
     References
    6 REPRESSION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS
     6.1. Repression of transcription
     6.2. Indirect repression
     6.3. Direct repression
     6.4. Inhibition by alteration of chromatin structure
     6.5. Inhibition of transcriptional elongation
     6.6. Conclusions
     References
    7 REGULATION OF TRANSCRIPTION FACTOR SYNTHESIS
     7.1. Transcription factor regulation
     7.2. Regulated synthesis of transcription factors
     7.3. Mechanisms regulating the synthesis of transcription factors
     7.4. Conclusions
     References
    8 REGULATION OF TRANSCRIPTION FACTOR ACTMTY
     8.1. Evidence for the regulated activity of transcription factors
     8.2. Regulation by protein-ligand binding
     8.3. Regulation by protein-protein interactions
     8.4. Regulation by protein modification
     8.5. Regulation by protein degradation and processing
     8.6. Role of regulated activity
     8.7. Conclusions
     References
    9. TRANSCRIPTION FACTORS AND HUMAN DISEASE
     9.1. Diseases caused by transcription factor mutations
     9.2. Cancer
     9.3. Cellular oncogenes and cancer
     9.4. Anti-oncogenes and cancer
     9.5. Transcription factors and treatment of human disease
     9.6. Conclusions
     References
    10. CONCLUSIONS AND FUTURE PROSPECTS