药物发现 = Drug discovery / [edited by] Du Guanhua. — Beijing : Science Press, 2007. – (63.3/D794r)

Contents

    目 录<br>    
    1 中文摘要
    疾病机理
    13 Mechanisms and inhibition of HIV integration
     HlV整合的机制和抑制作用
    21 Overcoming HlV-1 resistance to protease inhibitors
     克服HIV-1对蛋白酶抑制剂的耐药性<br>    27 Mechanisms of bacterial protein toxin entry into the target cell cytosol
     细菌毒素进入靶细胞质的机制<br>    33 Is the mycobacteriaI cell wall a hopeless drug target for latent tuberculosis?
     分支杆菌细胞壁无望成为潜伏性结核病的药物靶点?
    42 Tumor necrosis factor-α inhibitors and granulomatous infectious
     肿瘤坏死因子α抑制剂和肉芽肿侵染<br>    48 Could rheumatoid anhritis have an infectious aetiology?
     类风湿关节炎有传染性病因?
    53 Mechanisms of inflammatory response syndrome in sepsis
     败血病的炎症反应综合征产生机制<br>    疾病模型
    59 Models of cryptococcal meningitis
     隐球菌性脑膜炎模型
    66 Models for the study of respiratory syncytial vlrus infection and disease
     呼吸道合胞体病毒感染病的研究模型
    72 Can animal models predict protection provided by meningococcal vaccines?
     动物模型能够预测流脑菌苗的保护作用?
    77 Models of CMV infection
     巨细胞病毒感染模型<br>    83 ModeIs of HlV-1 disease：A review of current status
     HIV一1疾病模型的现状综述<br>    90 Modeling pathogen and host：in vitro，in vitro and in silico models of latent Mycobacterium tuberculosis infection
     模型病理和宿主：潜伏结核分枝杆菌感染的体外、体内和虚拟模型
    96 Advances in viral respiratory infections：new expe rimental models
     病毒呼吸道感染进展：新的实验模型
    103 ModeIs of HIV infection utilizing transgenic and reconstituted immunodeficient mice
     利用转基因和重建免疫缺陷小鼠制备HIV感染模型
    111 Experimental disease models of influenza virus infections：recent developments
     流感病毒感染实验疾病模型的最新进展<br>    118 Models for bacterial infectious diseases：Helicobacfer pylori
     幽门螺旋杆菌感染性疾病模型<br>    技术<br>    124 Techniques used for the discovery of therapeutic compounds：the case of SARS
     治疗性化合物的发现技术：SARS案例
    131 Predictlon of blood-brain barrier permeation in drug discovery from in vivo， in vitro and in silico models
     药物发现过程中药物透过血脑屏障的体内体外和计算机预测方法
    治疗策略
    141 Meningococcal diseases：From genomes to vaccines
     脑膜炎球菌病：从基因组到疫苗
    149 Overcoming the problem of chronic hepatitis B
     攻克慢性乙型肝炎的难题
    155 Progress in antifungal therapy：Echinocandins versus azoles
     抗真菌治疗的进展：棘球白素与唑类比较