化学生物学 = Chemical biology / [edited by] Xi Zhen. — Beijing : Science Press, 2007. – (58.173/C517b)

Contents

    目 录<br>    
    1 中文摘要
    化学生物学<br>    5 Enzymatic tools for engineering natural product glycosylation
     天然产物糖基化的工具酶<br>    14 Nucleic acid aptamers and enzymes as sensors
     作为传感器的核酸适配子和酶<br>    24 Catalytic antibodies and their applications
     催化抗体及其应用
    30 The evolution of DNA polymerases with novel activities
     新活性DNA聚合酶的人工进化
    38 Understanding enzyme action on immobilised substrates
     酶对固定化底物的作用
    46 Mining genomes and‘metagenomes’for novel catalysts
     从基因组和“宏基因组”中寻找新型催化剂<br>    52 Ultra-high-throughput screening based on cell-surface display and fluorescence-activated cell sorting for the identification of novel biocatalysts
     基于细胞表面展示及荧光活化细胞分类的超高通量筛选，寻找新型生物催化剂<br>    59 Improved β-lactam acylases and their use as industrial biocatalysts
     改良的β一内酰胺酰基转移酶及其作为工业生物催化剂的应用
    66 Enzyme catalysed deracemisation and dynamic kinetic resolution reactions
     酶催化的去消旋化和动态动力学拆分
    72 Peroxide-utilizing biocatalysts：structural and functional diversity of heme-containing enzymes
     利用过氧化物的生物催化剂：含有亚铁血红素的酶的结构与功能的多样性<br>    78 Hydrogenases：active site puzzles and progress
     氢化酶：活性位点之谜与进展
    86 Enantioselective biocatalysis optimized by directed evolution
     通过定向进化优化对映选择性生物催化剂
    95 Evolving haloalkane dehalogenases
     卤烷烃去卤化酶的人工进化
    105 Harnessing microbial activities for environmental cleanup
     利用微生物活性进行环境净化<br>    116 Bioethanol
    生物乙醇
    122 ChemicaI diversity through biotransformations
     生物转化带来的化学多样性<br>    130 Metabolic engineering of Escherichia coli and Corynebacterium for biotechnological production of organlc acids and amino acids
     生产有机酸和氨基酸的大肠杆菌与谷氨酰胺棒状杆菌的代谢工程
    137 Recent advances in oxygenase-catalyzed biotransformations
     加氧酶催化的生物转化的最新进展<br>    143 The soil metagenome-a rich resource for the discovery of novel natural products
     土壤宏基因组一发现新型天然产物的宝库<br>    149 Biocatalysis in pharmaceutical preparation and alteration
     药物制备与改造中的生物催化<br>    157 High-throughput screening of biocatalytic activity：applications in drug discovery
     生物催化活性的高通量筛选：在药物发现中的应用<br>    164 High-throughput screens and selections of enzyme-encoding genes
     酶编码基因的高通量筛选与精选<br>    171 Predicting enzyme function from protein sequence
     从蛋白质序列预测酶功能<br>    179 Synthesis and modifications of carbohydrates，using biotransformations
     应用生物转化进行碳水化合物的合成和修饰<br>    187 Whole organism biocatalysis
     全生物体生物催化