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The hippocampus book / edited by Per Andersen ... [et al.]. — Oxford : Oxford University Press, c2007.—(59.5978/H667h) |
Contents
Contents
Chapter 1 The Hippocampal Formation 3
1.1 Overview 3
1.2 Why Study the Hippocampal Formation on its Own? 4
1.3 Defining the Contemporary Era 5
1.4 Organization and Content of the Book 6
Chapter 2 Historical Perspective: Proposed Functions， Biological Characteristics， and Neurobiological Models of the Hippocampus 9
2.1 Overview 9
2.2 The Dawn of Hippocampal Studies 9
2.3 Early Ideas About Hippocampal Function lO
2.4 Special Features of Hippocampal Anatomy and Neurobiology 16
2.5 Several Neurophysiological Principles Have Been Discovered in Hippocampal Studies 23
2.6 Development of Methodological Procedures for General Use 26
Chapter 3 Hippocampal Neuroanatomy 37
3.1 Overview 37
3.2 Historical Overview of Hippocampal Nomenclature - What's in a Name? 39
3.3 Three-dimensional Organization and Major Fiber Systems of the Hippocampal Formation 44
3.4 Neuroanatomy of the Rat Hippocampal Formation 51
3.5 Chemical Neuroanatomy 94
3.6 Comparative Neuroanatomy of the Rat， Monkey， and Human Hippocampal Formation 95
3.7 Principles of Hippocampal Connectivity and Implications for Information Processing 107
3.8 Conclusions lO9
Chapter 4 Morphological Development of the Hippocampus 115
4.1 Overview 115
4.2 Neurogenesis and Cell Migration 115
4.3 Development of Hippocampal Connections 12o
4.4 Development of the Primate Hippocampal Formation 127
Chapter 5 Structural and Functional Properties of Hippocampal Neurons 133
5.1 Overview 133
5.2 CA1 Pyramidal Neurons 133
5.3 CA3 Pyramidal Neurons 153
5.4 Subicular Pyramidal Neurons 159
5.5 Dentate Granule Neurons 162
5.6 Mossy Cells in the Hilus 166
5.7 Pyramidal and Nonpyramidal Neurons of Entorhinal Cortex 169
5.8 Pyramidal and Nonpyramidal Neurons of Presubiculum and Parasubiculum 176
5.9 Local Circuit Inhibitory Interneurons 176
Chapter 6 Synaptic Function 203
6.1 Overview 203
6.2 General Features of Synaptic Transmission: Struc/it3re 204
6.3 Glutamatergic Synaptic Transmission 211
6.4 GABAergic Synaptic Transmission 218
6.5 Other Neurotransmitters 220
6.6 Special Features of Individual Hippocampal Synapses 222
6.7 Unresolved Issues 231
Chapter 7 Molecular Mechanisms of Synaptic Function in the Hippocampus: Neurotransmitter Exocytosis and Glutamatergic， GABAergic， and Cholinergic Transmission 243
7.1 Overview 243
7.2 Neurotransmitter Exocytosis 243
7.3 Glutamate Receptors: Structure， Function， and Hippocampal Distribution 249
7.4 Trafficking of Glutamate Receptors and Hippocampal Synaptic Plasticity 258
7.5 Glutamate Receptor Mutant Mice: Genetic Analysis of Hippocampal Function 263
7.6 GABAergic Receptors: Structure， Function， and Hippocampal Distribution 274
7.7 Trafficking of GABA Receptors and Hippocampal Synaptic Function 282
7.8 Genetic Analysis of GABA Receptor Function in the Hippocampus 283
7.9 Cholinergic Receptors 284
Chapter 8 Local Circuits 297
8.1 Overview 297
8.2 Dentate Gyrus 3Ol
8.3 Areas CA3 and CA1 305
8.4 Summary 314 References 315
Chapter 9 Structural Plasticity 321
9.1 Overview 321
9.2 Dendritic and Synaptic Plasticity in the Hippocampal Formation 321
9.3 Adult Neurogenesis 324
9.4 Possible Functions of New Neurons 332
Chapter 10 Synaptic Plasticity in the Hippocampus 343
10.1 Overview 343
10.2 Transient Activity-dependent Plasticity in Hippocampal Synapses 347
lO.3 NMDA Receptor-dependent Long-term Potentiation Properties and Determinants 350
10.4 NMDA Receptor-dependent LTP: Expression Mechanisms 369
lO.5 LTP at Mossy Fiber Synapses 398
lO.6 LTP Can Be Modulated by Other Neurotransmitters， Neuromodulators， and Effectors and by Endogenous and Circadian Rhythms 403
lO.7 Long-term Depression and Depotentiation: Properties and Mechanisms 407
10.8 Synaptic Plasticity and Inhibitory Pathways 420
10.9 LTP and LTD in Development and Aging and in Animal Models of Cognitive Dysfunction 422
lO.lO Functional Implications of Hippocampal Synaptic Plasticity 427
Chapter 11 Hippocampal Neurophysiology in the Behaving Animal 475
11.1 Overview 475
11.2 Hippocampal Electroencephalogram Can Be Classified into Distinct Patterns， with Each Providing Information About an Aspect of Hippocampal Function 477
11.3 Hippocampal Theta Activity 479
11.4 Non-theta EEG Patterns in the Hippocampal EEG: LIA， SIA， Ripples， Beta， and Gamma 483
11.5 Single-cell Recording in the Hippocampal Formation Reveals Two Major Classes of Units: Principal Cells and Theta Cells 486
11.6 Theta Cells 490
11.7 Complex-spike Cells and Spatial Processing 491
11.8 Place Cells Are Memory Cells 511
11.9 Head Direction Cells 517
11.10 Interactions Between Hippocampal Place Cells and Head Direction Cells 521
11.11 Hippocampal Complex-spike Cells Have Been Implicated in Nonspatial Perception and Learning 523
11.12 Other Distinctive Cells in the Hippocampal Formation and Related Areas 534
11.13 Overall Conclusions 538 References 540
Chapter 12 Functional Role of the Human Hippocampus 549
12.1 Overview 549
12.2 Patient H.M. 550
12.3 Methods for Studying Human Hippocampal Function 552
12.4 Dissociating Hippocampal Function 561
12.5 Conclusions 573
Chapter 13 Theories of Hippocampal Function 581
13.1 Overview 581
13.2 Cognitive and Behavioral Neuroscience， Interventional Techniques， and the Hippocampus 582
13.3. Declarative Memory Theory 591
13.4 Hippocampus and Space: Cognitive Map Theory of Hippocampal Function 617
13.5 Predictable Ambiguity: Configural， Relational， and Contextual Theories of Hippocampal Function 656
13.6 Episodic Memory， Hippocampus， and Neurobiology of Rapid Context-specifc Memory 677
Chapter 14 Computational Models of the Spatial and Mnemonic Functions of the Hippocampus 715
14.1 Overview 715
14.2 Introduction 715
14.3 Hippocampus and Spatial Representation 716
14.4 Hippocampus and Spatial Navigation 729
14.5 Hippocampus and Associative or Episodic Memory 733
14.6 Reconciling the Hippocampal Roles in Memory and Space 740
14.7 Conclusions 744
Chapter 15 Stress and the Hippocampus 751
15.1 Overview 751
15.2 Glucocorticoid Receptors and Hippocampal Function 753
15.3 Stress and Hippocampal Structure 759
15.4 Other Higher Brain Structures Implicated in Stress and Their Interaction with the Hippocampus 761
15.5 How the Hippocampus Orchestrates Behavioral Responses to Arousing Aversive Experiences 762
Chapter 16 Hippocampus and Human Disease 769
16.1 Overview 769
16.2 Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis 77o
16.3 Mzheimer's Disease 789
