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Biochemistry and physiology of the neutrophil / Steven W. Edwards. — Cambridge : Cambridge University Press, 1994.—(59.523/E26) |
Contents
Contents
Abbreviations Preface
page xii
xvii
1 Neutrophils and host defence: The fight against infection
1.1 The immune system
1.2 Cellular components of the immune system
1.3 Molecular components of the immune system
1.4 Neutrophil function during inflammation
1.5 Bibliography
2 The development and structure of mature neutrophils
2.1 Haematopoiesis
2.2 Properties of the CSFs
2.3 Interactions of CSFs and cytokines during haematopoiesis
2.4 Development of neutrophils
2.5 Morphology of the mature neutrophil
2.6 The antimicrobial granule enzymes
2.7 Bibliography
3 The generation and recognition of neutrophil-activating factors: Structure and function of neutrophil receptors
3.1 Leukotriene B4
3.2 Complement fragment C5a
3.3 Platelet activating factor (PAF)
3.4 Histamine
3.5 Cytokines
3.6 fMet-Leu-Phe
3.7 Purinergic receptors
3.8 Adhesion molecules involved in inflammation
3.9 Neutrophil integrins
3.10 Immunoglobulin receptors
3.11 Bibliography
4 The cytoskeleton: The molecular framework regulating cell shape and the traffic of intracellular components
4.1 The microfilaments
4.2 Microtubules
4.3 Intermediate filaments
4.4 Microtrabeculae
4.5 Changes in cytoskeletal arrangement during neutrophil activation
4.6 Changes in cytoskeletal structure during chemotaxis and phagocytosis
4.7 Bibliography
5 The respiratory burst: The generation of reactive oxygen metabolites and their role in microbial killing
5.1 Oxygen metabolism and neutrophil function
5.2 Oxygen， oxygen metabolites and toxicity
5.3 The respiratory-burst enzyme
5.4 Reactive oxidant production during the respiratory burst
5.5 Reactive nitrogen intermediates
5.6 Bibliography
6 Neutrophil activation: The production of intracellular signalling molecules
6.1 Introduction
6.2 G-proteins 189
6.3 Phospholipase activation 199
6.4 Protein kinases
6.5 Ion pumping
6.6 Bibliography
7 Neutrophil priming: Regulation of neutrophil function during inflammatory activation
7.1 Background
7.2 Mechanisms of priming
7.3 Protein biosynthesis in mature neutrophils
7.4 Bibliography
8 Disorders of neutrophil function
8.1 Introduction
8.2 Chronic granulomatous disease
8.3 Myeloperoxidase deficiency
8.4 Specific granule deficiency
8.5 Chediak-Higashi syndrome (CHS)
8.6 Hyperimmunoglobulin E-recurrent infections (Job' s syndrome)
8.7 CD 11/CD 18 leukocyte glycoprotein deficiency
8.8 Myelodysplastic syndromes (MDS)
8.9 Rheumatoid arthritis
8.10 Bibliography
