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Advances in immunology. v. 92 / edited by Frederick W. Alt. — Amsterdam : Elsevier, 2006. – (58.691/A244/v.92) |
Contents
Contents
Contributors
Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease
Abstract
1. Introduction
2. Immunological Alterations in SLE
3. Genetics of SLE Susceptibility in Humans.
4. Murine Models of SLE
5. Modeling Disease Development
References
Avian Models with Spontaneous Autoimmune Diseases
Abstract
1. Introduction
2. Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders
3. The OS Chicken: Model for Human Hashimoto Disease
4. The UCD-200 Line of Chickens: A Model for Human Systemic Sclerosis
5. The SL Chicken Model for Human Antoimmune Vitiligo
6. Conclusions and Outlook
References
Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
Abstract
1. Introduction
2. Phenotype of CD4+CD25+ nTreg Cells
3. Factors Regulating the Expansion and Specificity of nTreg Cells
4. Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells
5. Growth Factor-Mediated Control of nTreg Cell Development， Function， and Homeostasis
6. Control of Autoimmune Responses by nTreg Cells
7. Summary and Conclusions
References
BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation
Abstract
1. Overview of BTLA and HVEM Ligand Discovery
2. Structural Characterization of BTLA Bound to HVEM
3. Viral Modulators of the HVEM-BTLA Pathway
4. Expression arid Regulation of BTLA， LIGHT， and HVEM on T Cells and APCs
5. Mechanisms of the CD28 Family Inhibitory Receptors
6. Consequences of HVEM Ligation
7. BTLA and HVEM in Models of Disease
8. Conclusions
References
The Human T Cell Response to Melanoma Antigens
Abstract
1. Introduction
2. Melanoma Antigens
3. Measurement of Antigen-Specific T Cell Responses
4. Naturally Acquired Tumor Antigen-Specific T Cell Responses
5. Vaccine-Induced T Cell Responses
6. Regulation of Tumor Antigen-Specific T Cell Responses
7. Conclusions
References
Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions
Abstract 226
1. Host-Pathogen Interactions 227
2. Manipulation of the Host Response by Pathogens: Some
General Considerations 229
3. Antigen Presentation 230
4. Class I MHC Antigen Presentation 230
5. Pathogen Recognition by CD8+ T Cells and NK Cells 232
6. Class II MHC Antigen Presentation 233
7. Ubiquitin-Proteasome System 234
8. The Ubiquitin Conjugation Cascade 234
9. Ubiquitin Ligases 236
10. Ubiquitin Chains and Ubiquitin-Like Modifiers (Ubls) 237
11. Deubiquitinating Enzymes 239
12. The Proteasome 239
13. ER Quality Control and Degradation 240
14. ERAD Substrate Recognition 241
15. ERAD E3 Ligases 243
16. Mammalian ERAD E3s 244
17. The Elusive Dislocon 247
18. Driving Dislocation and the Ub-Binding Route to the Proteasome 247
19. Peptide N-Glycanase 249
20. Viral Interference with Class I MHC Antigen Presentation 250
21. Human Cytomegalovirus 251
22. HCMV Interference with Class I MHC Antigen Presentation 251
23. Dislocation from the ER: HCMV USll and US2 254
24. Signal Peptide Peptidase Is Required for Dislocation from the ER 255
25. SPP and Generation of HLA-E Epitopes 256
26. SPP and Processing of the Hepatitis C Virus Core Protein 256
27. SPP and Calmodulin Signaling 257
28. SPP Peptide Peptidase and Development 257
29. SPP and ER Quality Control 258
30. Three Routes of Pathogen-Mediated El/Protein Disposal 261
31. Pathogen Interference with Class II MHC Antigen Presentation 264
32. Inhibition of Recognition at the Surface of the APC 264
33. Class II MHC Downregulation from the Surface of the APC 265
34. CD4 Downregulation from the Surface of the CD4+ T Cell
35. Pathogen Manipulation of the Ubiquitin-Proteasome System
36. Interference with Proteasomal Proteolysis
37. Control of Infection
38. Virus Budding
39. Bacterial Chromosome Integration
40. ISGylation and deISGylation
41. Control of Inflammation
42. Posttranscriptional Gene Silencing
43. Downregulation of Cell Surface Receptors by Pathogen-Encoded E3s
44. Programmed Cell Death in Plants
45. Cytokine Responses
46. Pathogen-Encoded DUBs
47. Conclusions and Future Directions
References
Index
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