The organic chemistry of drug design and drug action = 药物设计与药物行为的有机化学 / Richard B. Silverman. — 2nd ed., [Reprinted ed.]. — Beijing : Science Press ; [Amsterdam] : Elsevier, 2007.—(63.371/S587(R)/2nd ed.)

Contents

    Contents
    
    Preface to the First Edition
    Preface to the Second Edition
    1 Introduction
    1.1 Medicinal Chemistry Folklore
    1.2 Discovery of New Drugs
    1.3 General References
    1.4 References
    2 Drug Discovery， Design， and Development
    2.1 Drug Discovery
    2.2 Lead Modification: Drug Design and Development
    2.3 General References
    2.4 Problems
    2.5 References
    3 Receptors
    3.1 Introduction
    3.2 Drug-Receptor Interactions
    3.3 General References
    3.4 Problems
    3.5 References
    4 Enzymes
    4.1 Enzymes as Catalysts
    4.2 Mechanisms of Enzyme Catalysis
    4.3 Coenzyme Catalysis
    4.4 Enzyme Therapy
    4.5 General References
    4.6 Problems
    4.7 References
    5 Enzyme Inhibition and Inactivation
    5.1 Why Inhibit an Enzyme?
    5.2 Drug Resistance
    5.3 Drug Synergism (Drug Combination)
    5.4 Reversible Enzyme Inhibitors
    5.5 Irreversible Enzyme Inhibitors
    5.6 General References
    5.7 Problems
    5.8 References
    6 DNA-Interactive Agents
    6.1 Introduction
    6.2 DNA Structure and Properties
    6.3 Classes of Drugs That Interact with DNA
    6.4 Epilogue to Receptor-Interactive Agents
    6.5 General References
    6.6 Problems
    6.7 References
    7 Drug Metabolism
    7.1 Introduction
    7.2 Synthesis of Radioactive Compounds
    7.3 Analytical Methods in Drug Metabolism
    7.4 Pathways for Drug Deactivation and Elimination
    7.5 General References
    7.6 Problems
    7.7 References
    8 Prodrugs and Drug Delivery Systems
    8.1 Enzyme Activation of Drugs
    8.2 Mechanisms of Drug Activation
    8.3 General References
    8.4 Problems
    8.5 References
    Appendix Answers to Chapter Problems
    Index