1.       The Matric Metalloproteinases and Their Inhibitors  3

2.       Genetic Regulation of the Matrix Metalloproteinases and Related Proteins  19

3.       Post-Translational Modification  67

4.       Substrates for Metalloendopeptidases in the Central Nervous System  87

5.       Examples of Signalling by MMPs  119

6.       Metalloproteinases in Development-Breaking Things Down to Build a Nervous System  153

7.       Matrix Metalloproteinases in Myelin Formation  189

8.       TIMPs in CNS Development  207

9.       Matrix Metalloproteinases in Cerebral Ischemia  227

10.   Are Matrix Metalloproteinases Detrimental or Beneficial to Artherosclerosis?  249

11.   Role and Regulation of Matrix Metalloproteases in Brain Tumours  263

12.   Matrix Metalloproteinases and Related Proteins in Alzheimer’s Disease, Parkinson’s Disease and Other Neurodegenerative Disorders  279

13.   Tissue Inhibitors of Martix Metalloproteinases, Inflammation and The Central Nervous System  311