Oncogenomics molecular approaches to cancer / edited by Charles Brenner, David Duggan. -- Wiley-Liss, 2004. -- 64.83/O58m

Contents

Contents:

1. At the Precarious Cusp of Oncogenomics  3

2. Genome-Wide Searches for Mutations in Human Cancer  17

3. Molecular Cytogenetics: Increasing Resoulution Using Array-Based CGH  37

4. SNPs and Functional Polymorphisms in Cancer  57

5. Expression Profiling of Breast Cancer: From Molecular Portraits to Clinical Utility  77

6. Classifying Hereditary Cancers and Phenocopies of Hereditary Cancers Using Expression Arrays  101

7. Linking Drugs and Genes: Pharmacogenomics, Pharmacoproteomics, bioinformatics, and the NCL-60  117

8. Tissue Microanalysis: Profiling Cancer Stages  139

9. Proteomics in bladder Cancer  157

10. Chemical and Genetic Methods to Validate Tragets in Nonmammalian Organisms  187

11. Mouse Models of Cancer  199

12. Genome-Wide Modifier Screens: Hpw the Genetics  of Cancer Penetrance May Shape the Future of Prevention and Treatment  255

13. Protein Kinases As Targets in Cancer Therapy: Validated and Emerging Approaches  293

14. RAS Superfamily-Directed Compounds  317

15. Clinomics: Postgenomic Cancer Care  341

16. Oncogenomics and the NCI Director's Vision For 2015  361