Epigenetics in health and disease. Part B / edited by Vijai Singh, Indra Mani. -- Amsterdam : Academic Press, 2023. – (58.178/P964/v.198)

Contents

Contributors
Preface
 1. Applications of bioinformatics in epigenetics
     1. Introduction
      2. Epigenetic data processing and analysis
      3. Epigenetics databases
      4. In silico tools for epigenetic modification
      5. Conclusion and future perspectives
      Conflict of interest
      References
2. CRISPR-dCas9 system for epigenetic editing towards therapeutic applications
     1. Introduction
      2. Approaches of epigenome modification using CRISPR-dCas9
      3. Conclusions and future remarks
      Acknowledgments
      References
3. Epigenetic control of heredity
      1. Introduction
      2. Epigenetic inheritance
      3. Epigenetic control on gene expression
      4. DNA methylation and heredity
      5. Histone modifications and heredity
      6. Non-coding RNAs and heredity
      7. Factors influencing epigenesis, associated diseases and their inheritance
      8. Role of epigenetic inheritance in heritability of diseases
      9. Conclusions
      10. Future perspective
      Acknowledgments
      Conflict of interest
      References
4. Epigenetics in renal diseases
      1. Introduction
      2. Epigenetic mechanisms in renal diseases
      3. Conclusion and future perspectives
      Conflict of interest
      References
5. Epigenetics in cancer development, diagnosis and therapy
      1. Introduction
      2. Epigenetics and cancer development
      3. Epigenetics and cancer diagnosis
      4. Epigenetics and cancer therapy
      5. Conclusion and future direction
      Acknowledgments
      References
6. Microbiota and epigenetics: Health impact
      1. Introduction
      2. Epigenetic processes
      3. Interaction among diet, microbiome, and epigenetics
     4. Epigenetics and microbiome in the diseased states
      5. Therapeutic approaches
      6. Conclusion
      7. Future perspective
      References
7. Histone deacetylase (HDACs) inhibitors: Clinical applications
      1. Introduction
      2. The roles of HDACs in cancer
      3. HDAC inhibitors in neurodegenerative diseases
      4. HDACi in cardiovascular diseases
      5. Conclusions
      References
 8. Early epigenetic markers for precision medicine
      1. Introduction
      2. What is epigenetics?
      3. Epigenetic modifications
      4. Role of epigenetics in biological processes
      5. Epigenetics in cancer
      6. Epigenetic in neurological disorders
      7. Conclusions
      References
 9. Epigenetics of neurological diseases
      1. Introduction
      2. Epigenetic layers and their regulators
      3. Epigenetic dysregulation in neurological disorders
      4. Therapeutic potential
      5. Conclusion
      References
10. Epigenetic regulons in Alzheimer's disease
      1. introduction
      2. Epigenetic mechanisms
      3. Environmental factors in the progression of AD
      4. Epigenetic mechanisms in Alzheimer's disease (AD)
      5. Epigenetic therapeutics in AD
      6. Conclusions
      Acknowledgments
      Conflict of interest
      References
11. Epigenetics in epilepsy
      1. introduction
      2. Epigenetic modifications in epilepsy
      3. Therapeutic prospects
      4. Conclusion
      References
Index