The regulatory genome in adaptation, evolution, development, and disease / by Moyra Smith. -- London : Academic Press , 2023. – (58.21/S655)

Contents

Preface  xiii
Acknowledgments  xv
Epigraph  xvii
I  Progress in determining key elements in regulation of gene expression
1. Gene regulation in physiological processes
2. Epigenetics, the nonprotein coding genome, and human accelerated sequences
II  Evolution and adaptation
3. Gene expression and regulation relative to specific tissues and functions
4. Evo-Devo and morphological diversity
5. Adaptation and evolution
6. Adaptations metabolic and genomic to environmental changes
III  Adaptation
7. Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders
8. Altered gene expression associated with developmental defects and disease
9. Metabolic, epigenetic functions and correlations with phenotype
10. Aging, genomic mitochondrial, and regulatory changes
IV  Altered gene expression associated with developmental defects and disease
11. The regulatory genome and defects in monogenic diseases
12. Epigenetics and human disease
13. Connecting developmental defects and evolutionary findings
14. The regulatory genome and complex common diseases
Index  389