Advances in immunology. Volume 158 / edited by Frederick W. Alt, Kenneth M. Murphy -- Amsterdam : Elsevier, c2023. – (58.691/A244/v.158)

Contents

Contributors
1. RIG-I-like receptors: Molecular mechanism of activation and signaling
    1. RIG-I-like receptors activate antiviral immune responses
    2. MDA5 complements RIG-I in targeting a broad spectrum of viral infections
    3. LGP2 shares more homology to MDA5 than to RIG-I
    4. MAVS on mitochondria and its downstream interaction
    5. Molecular basis of the genetic diseases associated with RLRs
    6. Development of therapeutics targeting RLRs
    Acknowledgments
    Conflict of interest
    References
2. Regulation of gasdermins in pyroptosis and cytokine release
    1. Introduction
    2. Processing of gasdermins by host proteases
    3. Regulation of GSDMB and GSDMD through ubiquitination
    4. Cys modifications in gasdermins that regulate pyroptosis
    5. Phosphorylation of gasdermins
    6. The roles of gasdermins in cytokine release
    7. Conclusions and future perspectives
    Acknowledgments
    Declaration of competing interest
    Author contributions
    References